Cancer, GI, and Toxicology Drugs Flashcards
What are the rescue drugs for the following anti-Cancer drugs? > Methotrexate > Cyclophosphamide > Doxorubicin > Cisplatin
> Methotrexate –> Leucovorin
Cyclophosphamide –> Mesna
Doxorubicin –> Dexrazoxane
Cisplatin –> Amifostine
What is are the commonly used drugs for:
Acute Lymphocytic Leukemia in children
Prednisone, Vincristine, and Asparaginase or an Anthracycline plus intrathecal Methotrexate
What is are the commonly used drugs for:
AML in adults
Cytarabine and Idarubicin or Daunorubicin
What is are the commonly used drugs for:
Breast Carcinoma
Cytotoxic agents, hormonal therapy with Tamoxifen or an Aromatatse inhibitor (anostrozole), TRASTUZUMAB
What is are the commonly used drugs for:
CML
Imatinib newer tyrosine kinase inhibitors, interferon
What is are the commonly used drugs for:
Colon Carcinoma
Fluorouracil plus Leucovorin plus Oxaliplatin
What is are the commonly used drugs for:
Hodgkin’s Lymphoma
ABVD regimen: doxorubicin (Adriamycin), Bleomycin, Vincristine, Dacarbazine, and Prednisone
What is are the commonly used drugs for:
NHL
CHOP regimen: Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) plus Rituximab
What is are the commonly used drugs for:
Ovarian Carcinoma
Paclitaxel and Carboplatin
What is are the commonly used drugs for:
Pancreatic Carcinoma
Gemcitabine and Erlotinib
What is are the commonly used drugs for:
Prostate Carcinoma
GnRH agonist (Leuprolide) or antagonist (Abarelix) and androgen receptor antagonist (Flutamide)
What is are the commonly used drugs for:
Lung Ca
Carboplatin, Paclitaxel, and Bevacizumab
What is are the commonly used drugs for:
Testicular Carcinoma
PEB regimen: Cisplatin (Platinol), Etoposide, and Bleomycin
Activated Charcoal is EFFECTIVE for:
Amitryptiline / Barbiturates Carbamazepine / Digitalis Glycosides Phencyclidine / Propoxyphene Theophyline . TCA Valproic acid
Activated Charcoal is NOT effective for:
Iron / Lithium / Potassium / Alcohols / Cyanide / Corrosive / Acids / Solvents
Utility of Hemodialysis EFFECTIVE for:
Carbamazepine / Ethylene glycol / Lithium / Methanol / Metformin / Phenobarbital / Salicylate / Theophylline / Valproic acid
Utility of Hemodialysis NOT effective for:
Amphetamines / Antidepressants / Antipsychotic drugs / Benzodiazepines / Calcium channel blockers / Digoxin / Metoprolol / Propranolol / Opioids
What is the antidote for Acetaminophen?
Acetylcysteine
What is the antidote for Cholinesterase inhibitors?
Atropine
What is the antidote for Quinidine, TCAs?
Bicarbonate
What is the antidote for Fluoride, CCBs?
Calcium
What is the antidote for Iron?
Deferoxamine
What is the antidote for Digoxin?
Digoxin antibodies (Digibind)
What is the antidote for Caffeine, theophylline, sympathomimetics?
Esmolol
What is the antidote for Methanol, ethylene glycol?
Ethanol
What is the antidote for Benzodiazepines, zolpidem?
Flumazenil
What is the antidote for Methanol, ethylene glycol?
Fomepizole
What is the antidote for Beta adrenoceptor blockers?
Glucagon
What is the antidote for Hypoglycemics?
Glucose
What is the antidote for Cyanide?
Hydroxocobalamin
What is the antidote for Opioid analgesics?
Naloxone
What is the antidote for Carbon monoxide?
Oxygen
What is the antidote for Muscarinic receptor blockers?
Physostigmine
What is the antidote for Organophosphates?
Pralidoxime
What is the antidote for Heparin?
Protamine sulfate
What is the antidote for Warfarin?
Vitamin K, FFP
