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Pharmacology > Cancer, GI, and Toxicology Drugs > Flashcards

Cancer, GI, and Toxicology Drugs Flashcards

1
Q 
What are the rescue drugs for the following anti-Cancer drugs?
> Methotrexate
> Cyclophosphamide
> Doxorubicin
> Cisplatin
A

> Methotrexate –> Leucovorin
Cyclophosphamide –> Mesna
Doxorubicin –> Dexrazoxane
Cisplatin –> Amifostine

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2
Q

What is are the commonly used drugs for:

Acute Lymphocytic Leukemia in children

A

Prednisone, Vincristine, and Asparaginase or an Anthracycline plus intrathecal Methotrexate

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3
Q

What is are the commonly used drugs for:

AML in adults

A

Cytarabine and Idarubicin or Daunorubicin

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4
Q

What is are the commonly used drugs for:

Breast Carcinoma

A

Cytotoxic agents, hormonal therapy with Tamoxifen or an Aromatatse inhibitor (anostrozole), TRASTUZUMAB

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5
Q

What is are the commonly used drugs for:

CML

A

Imatinib newer tyrosine kinase inhibitors, interferon

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6
Q

What is are the commonly used drugs for:

Colon Carcinoma

A

Fluorouracil plus Leucovorin plus Oxaliplatin

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7
Q

What is are the commonly used drugs for:

Hodgkin’s Lymphoma

A

ABVD regimen: doxorubicin (Adriamycin), Bleomycin, Vincristine, Dacarbazine, and Prednisone

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8
Q

What is are the commonly used drugs for:

NHL

A

CHOP regimen: Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) plus Rituximab

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9
Q

What is are the commonly used drugs for:

Ovarian Carcinoma

A

Paclitaxel and Carboplatin

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10
Q

What is are the commonly used drugs for:

Pancreatic Carcinoma

A

Gemcitabine and Erlotinib

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11
Q

What is are the commonly used drugs for:

Prostate Carcinoma

A

GnRH agonist (Leuprolide) or antagonist (Abarelix) and androgen receptor antagonist (Flutamide)

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12
Q

What is are the commonly used drugs for:

Lung Ca

A

Carboplatin, Paclitaxel, and Bevacizumab

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13
Q

What is are the commonly used drugs for:

Testicular Carcinoma

A

PEB regimen: Cisplatin (Platinol), Etoposide, and Bleomycin

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14
Q

Activated Charcoal is EFFECTIVE for:

A 
Amitryptiline / Barbiturates
Carbamazepine / Digitalis Glycosides
Phencyclidine / Propoxyphene
Theophyline . TCA
Valproic acid
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15
Q

Activated Charcoal is NOT effective for:

A

Iron / Lithium / Potassium / Alcohols / Cyanide / Corrosive / Acids / Solvents

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16
Q

Utility of Hemodialysis EFFECTIVE for:

A

Carbamazepine / Ethylene glycol / Lithium / Methanol / Metformin / Phenobarbital / Salicylate / Theophylline / Valproic acid

17
Q

Utility of Hemodialysis NOT effective for:

A

Amphetamines / Antidepressants / Antipsychotic drugs / Benzodiazepines / Calcium channel blockers / Digoxin / Metoprolol / Propranolol / Opioids

18
Q

What is the antidote for Acetaminophen?

A

Acetylcysteine

19
Q

What is the antidote for Cholinesterase inhibitors?

A

Atropine

20
Q

What is the antidote for Quinidine, TCAs?

A

Bicarbonate

21
Q

What is the antidote for Fluoride, CCBs?

A

Calcium

22
Q

What is the antidote for Iron?

A

Deferoxamine

23
Q

What is the antidote for Digoxin?

A

Digoxin antibodies (Digibind)

24
Q

What is the antidote for Caffeine, theophylline, sympathomimetics?

A

Esmolol

25
Q

What is the antidote for Methanol, ethylene glycol?

A

Ethanol

26
Q

What is the antidote for Benzodiazepines, zolpidem?

A

Flumazenil

27
Q

What is the antidote for Methanol, ethylene glycol?

A

Fomepizole

28
Q

What is the antidote for Beta adrenoceptor blockers?

A

Glucagon

29
Q

What is the antidote for Hypoglycemics?

A

Glucose

30
Q

What is the antidote for Cyanide?

A

Hydroxocobalamin

31
Q

What is the antidote for Opioid analgesics?

A

Naloxone

32
Q

What is the antidote for Carbon monoxide?

A

Oxygen

33
Q

What is the antidote for Muscarinic receptor blockers?

A

Physostigmine

34
Q

What is the antidote for Organophosphates?

A

Pralidoxime

35
Q

What is the antidote for Heparin?

A

Protamine sulfate

36
Q

What is the antidote for Warfarin?

A

Vitamin K, FFP

Pharmacology (9 decks)

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