Endocrine Flashcards

1
Q

A 22yo presents with polyuria and polydipsia. Random blood glucose level was elevated

A

T1DM

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2
Q

A 45yo obese man presents with fatigue. Blood tests reveal an elevated Hba1c

A

T2DM

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3
Q

A known diabetic presents with altered consciousness, vomiting and acetone breath

A

Diabetic ketoacidosis

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4
Q

A known diabetic presents to the ED with altered mental status. Ketones are not elevated

A

Hyperosmolar coma

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5
Q

A female patient presents with fatigue, anorexia and weight loss. She also complains of palpitations and salt cravings. On examination, hyperpigmentation of the buccal mucosa is noted

A

Primary adrenal insufficiency (Addison’s disease)

Other causes: TB, malignancy, some drugs

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6
Q

A female patient presents with insidious onset weight gain and change in menstrual habits. On examination, a buffalo hump is noted as well as striae

A

Cushing’s syndrome

Causes: Cushing’s disease, ectopic ACTH-secreting tumours, ectopic CRF, exogenous corticosteroid exposure

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7
Q

A 30yo patient presents with lethargy, nocturia and polyuria. On examination, they are hypertensive

A

Conn’s syndrome

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8
Q

A 30yo patient presents to the ED in hypertensive crisis. They also complain of a headache and palpitations. The patient’s partner noted they have had a few similar episodes to this in the past involving headache, palpitations, sweating and pallor

A

Phaeochromocytoma

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9
Q

A 33yo female presents with weight loss despite increased appetite and menstrual irregularities. On further questioning she also admits to some palpitations. On examination, a lid lag is noticed

A

Hyperthyroidism (Graves’ disease)

Other causes: toxic multinodular goitre, iodine-induced, factitious, transient

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10
Q

A 40yo female with a history of coeliac disease presents with weight gain despite decreased appetite and constipation. On examination, reflexes are slowed

A

Hypothyroidism

Causes: autoimmune (Hashimoto’s), iatrogenic, drugs, congenital, iodine deficiency, infiltrative disorders

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11
Q

A 40yo female presents with a neck swelling. She has noted some hoarseness. She has no symptoms of hypo- or hyperthyroidism. US of the neck shows increased iodine uptake

A

Thyroid neoplasia

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12
Q

A 25yo female presents with a tremors and palpitations. On examination, a thyroid nodule is palpable

A

Toxic thyroid adenoma

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13
Q

A 22yo male presents with decreased libido. He has little body hair. On examination, his testicles are

A

Classical androgen deficiency

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14
Q

A 66yo overweight individual presents with inability to maintain an erection, fatigue and malaise. He has numerous CVD risk factors

A

Non-classical androgen deficiency

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15
Q

A patient presents with a headache associated with bitemporal hemianopia. The patient goes on to develop rhinorrhoea

A

Pituitary mass lesion (mass effect)

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16
Q

A 30yo female presents with amenorrhoea and galactorrhoea. FSH and LH levels are normal

A

Prolactinoma

17
Q

A 45yo patient presents with carpal tunnel syndrome and fatigue. On examination, coarse facial features are noted

A

Acromegaly

18
Q

Cold intolerance, weight gain, constipation, dry skin, slow reflexes Relevant pituitary hormone level?

A

Low TSH

19
Q
  • Weight loss with increased appetite
  • Heat intolerance, sweating
  • Tremulousness
  • Tachycardia and palpitations (AF, SVT), cardiomegaly and CHF
  • Anxiety, emotional lability
  • Loss of hair
  • Increased frequency of bowel movements or diarrhoea
  • Menstrual irregularity
  • Goitre
  • Uncommonly: pretibial myxoedema, onycholysis
  • Eye signs: redness and irritation, staring appearance, mild double vision on right extreme gaze

Relevant pituitary hormone level?

A

High TSH

20
Q

Small stature in children, or central adiposity and reduced muscle mass in adults Relevant pituitary hormone level?

A

Low GHRH

21
Q
  • Coarsening of facial features: frontal bossing, enlarged nose, jaw enlargement, macroglossia
  • Skin thickness and tags
  • Increased sweating
  • Carpal tunnel syndrome
  • Joint pain and dysfunction
  • Reduced libido, infertility, amenorrhoea, galactorrhoea, erectile dysfunction
  • Fatigue
  • Increased CV risk
  • Organomegaly

Relevant pituitary hormone level?

A

High GHRH

22
Q

Infertility, amenorrhoea/oligomenorrhoea, hot flushes, reduced bone and muscle mass, delayed puberty, erectile dysfunction, reduced libido failure to thrive or short stature in children

Relevant pituitary hormone level?

A

Low FSH/LH

23
Q

Hypoglycaemia, hypotension, nausea and vomiting, fatigue, weakness and dizziness

Relevant pituitary hormone level?

A

Low ACTH

24
Q
  • Hypertension and water retention
  • Ache and hirsutism
  • Weight gain: central obesity, supraclavicular and dorsocervical (buffalo hump) fat pads, moon face
  • Facial rounding and plethora
  • Proximal muscle weakness and buttocks wasting
  • Thinning of the skin, striae, plethoric face and bruising
  • Psychiatric symptoms: depression, anxiety, (psychosis)
  • Menstrual irregularities, decreased libido and inability to get pregnant
  • Linear growth deceleration in children
  • Metabolic complications including IGT/diabetes mellitus, dyslipidaemia, metabolic bone disease (osteopaenia), hypertension

Relevant pituitary hormone level?

A

High ACTH

25
Q

Loss of lactation after delivery

Relevant pituitary hormone level?

A

Low prolactin

26
Q
  • Women: hypogonadism (infertility, amenorrhoea/oligomenorrhoea), galactorrhoea
  • Men: hypogonadism (decreased libido, infertility, impotence, gynaecomastia), rarely galactorrhoea

Relevant pituitary hormone level?

A

High prolactin

27
Q
  • Euvolaemic hyponatraemia: anorexia, nausea, malaise
  • Severe hyponatraemia may result in headache, muscle cramps, irritability, confusion, seizures, coma
  • Severe hyponatraemia may result in headache, muscle cramps, irritability, confusion, seizures, coma
  • High urine osmolarity

Relevant pituitary hormone level?

A

High ADH

28
Q

A broad group of disorders characterised by thyroid inflammation. What are some types?

A

Thyroiditis

  • Pain: subacute, infectious, radiation, trauma
  • Painless: silent (post-partum, drugs), chronic lymphocytic, fibrous
29
Q

A unilateral adrenal mass is found on CT as an incidental finding. The patient has no symptoms

A

Adrenocortical neoplasia: “incidentaloma”