Endo week 2 Flashcards
give example of glycoprotein hormones.
give example of glycoprotein hormones.
Answer: TSH, LH, FSH
give example of catecholamines hormones.
give example of catecholamines hormones.
Answer: dopamine, epinephrine, norepinephrine.
give example of eicosanoids hormones.
give example of eicosanoids hormones.
Answer: prostaglandin
give examples of hormones with intracellular receptors?
give examples of hormones with intracellular receptors?
Answer: steroid hormones, thyroid hormones
what regulates hormone secretion?
what regulates hormone secretion?
Answer:
- other hormones
- neural mechanism
- concentration of electrolytes // other nutrients
characteristics of steroid hormones?
characteristics of steroid hormones?
Answer:
- derived from cholesterol
- not stored, but made on demand
- transported in blood bound
- receptor is intracellular
- can be administered orally
characteristics of protein/peptide hormones?
characteristics of protein/peptide hormones?
Answer:
- synthesized prepro -> pro -> active hormone
- stored
- travels unbound
- membrane receptor
- not administered orally (usually injection)
are all steroid hormones the end products of the pathway?
are all steroid hormones the end products of the pathway?
Answer: no,
exp; progesterone is not an end product and it is an active hormone.
the initial step of steroidogenesis, is the conversion of cholesterol to _________ via the enzyme ______
the initial step of steroidogenesis, is the conversion of cholesterol to ___pregnenolone______ via the enzyme ___cytochrome P450___
testosterone is converted to estrogen using the enzyme ?
testosterone is converted to estrogen using the enzyme ?
Answer: aromatase
majority of testosterone in females comes from the?
majority of testosterone in females comes from the?
Answer: adrenal cortex
a deficiency in 21 Beta- hydroxylase causes what?
a deficiency in 21 Beta- hydroxylase causes what?
Answer:
- no aldosterone or cortisol, but more sex hormones made.
- more pregnenolone is shunted to the DHEA-Androstenedione pathway resulting in virilization.
virilization = women develop masculine traits (excess hair)
what is the effect of estrogen on the liver during pregnancy?
what is the effect of estrogen on the liver during pregnancy?
Answer:
In pregnancy estrogen effects liver to increase binding protein synthesis. This results in increase level of bound hormones (to binding protein) and decrease level of free hormones.
what is transcortin?
what is transcortin?
Answer:
binding hormone for cortisol, aldosterone
what is SHBG?
what is SHBG?
Answer: sex-hormone binding globulin (bind testosterone, estrogen)
