ENDO VS. EXO TOXINS Flashcards
bacterial source: exotoxins
G+ and G-
bacterial source: endotoxins
G- only
location in the bacterium: exotoxins
synthesized in the cytoplasm, may or may not be secreted
location in the bacterium: endotoxins
outer membrane, characteristic of G- cell wall
chemical nature: exotoxins
protein
chemical nature: endotoxins
the lipid A component of lipopolysaccharide
ability to form a toxoid: exotoxins
generally, yes
ability to form a toxoid: endotoxins
no
heat stability: exotoxins
generally inactivated by heat
heat stability: endotoxins
heat stable
mechanism: exotoxins
distinct toxic mechanism for each
mechanism: endotoxins
innate immune response; systemic response can lead to septic shock and disseminated intravascular coagulation
toxicity: exotoxins
generally very potent; some are among the most toxic known toxins
toxicity: endotoxins
small amounts in a localized area lead to an appropriate immune response that clears an infection; systemic distribution can be deadly
G+ and G-
exotoxins
G- only
endotoxins
synthesized in the cytoplasm
exotoxins
may or may not be secreted
exotoxins
found in the outer membrane
endotoxins
characteristic of G- cell wall
endotoxin
protein
exotoxin
lipid A component of lipopolysaccharide
endotoxin
generally able to form a toxoid
exotoxin
unable to form a toxoid
endotoxin
heat-stable
endotoxin
generally inactivated by heat
exotoxin
distinct toxic mechanism for each
exotoxin
innate immune response
endotoxin
systemic response can lead to septic shock and disseminated intravascular coagulation
endotoxin
generally very potent
exotoxin
among the most toxic know toxins
exotoxin
small amount in localized areas trigger an appropriate immune response to clear an infection
endotoxin
systemic distribution can be deadly
endotoxin
