EMT Pharmacology - Prednisolone & Prednisone

Question 1

Pharmacology and presentation of Prednisolone and Prednisone?

Answer 1

5mg or 20mg Prednisone Tablets
5mg/ml Prednisolone Syrup

Prednisone is metabolised to Prednisolone in the liver. Prednisolone is a cortico-steroid with anti-inflammatory and immuno-suppressive actions. Inhibits production of inflammatory mediators (prostaglandins and leukotrienes) resulting in a reduced immune and inflammation response.

Question 2

Indicators of Prednisolone and Prednisone?

Answer 2

• Bronchospasm associated with asthma or COPD
• Croup
• Minor allergy associated with rash
• Prominent rash associated with anaphylaxis after all systemic signs of anaphylaxis have resolved

Question 3

Contraindications of Prednisolone and Prednisone?

Answer 3

• Known severe allergy

Question 4

Cautions of Prednisolone and Prednisone?

Answer 4

• Age less than 5 years, with asthma

Question 5

Side Effects of Prednisolone and Prednisone?

Answer 5

• Fatigue
• Sodium and Water Retention
• GI Reflux

Question 6

Dosing Regimes of Prednisolone and Prednisone?

Answer 6

• 40mg for an Adult

- Paediatrics 1mg per kg

Question 7

Onset and duration of Prednisone and Prednisolone?

Answer 7

Onset
‐ 30 to 60 mins

Duration
- 24 hours