E2 Erdman Monobactams

Question 1

only monobactam available

Answer 1

aztreonam

Question 2

aztreonam binds preferentially to ____ in aerobic (GN/GP) bacilli

Answer 2

PBP-3
GN
***

Question 3

T or F:
aztreonam has GN and GP coverage

Answer 3

false, only GN

Question 4

T or F:
aztreonam is active against anaerobes

Answer 4

false

Question 5

is aztreonam active against pseudomonas aeruginosa?

Answer 5

yes

Question 6

dosage form(s) of aztreonam

Answer 6

only IV

Question 7

does aztreonam penetrate CSF?

Answer 7

yes but only w/ inflamed meninges

Question 8

aztreonam elimination

Answer 8

urine as unchanged drug

Question 9

aztreonam half life

Answer 9

short, 1.3-2.2 hours

Question 10

is aztreonam removed by hemodialysis?

Answer 10

yes

Question 11

does aztreonam need adjustment with renal dysfunction?

Answer 11

yes

Question 12

clinical uses aztreonam

Answer 12

• infections due to susceptible GN aerobes
• pts with significant penicillin allergies*

Question 13

general AEs for aztreonam

Answer 13

• hypersens
• GI upset
• lft inc
• phlebitis
• the -enias