E1.hemolymphatic system Flashcards
What are the main components of the hematopoietic system? (7)a
– cellular elements of the blood – bone marrow – spleen – lymph nodes – thymus – accessory lymphoid tissue – mononuclear phagocyte system
One of the three stages/periods in hematopoiesis? (Two end in period the others just a flat name)
Prenatal period, postnatal period, and adults
Where does hematopoiesis happen in the prenatal period?
The yolk sac, fetal in liver, spleen, thymus, lymph nodes, bone marrow
Where does hematopoiesis happen in the post natal period?
Bone marrow
Where do you see hematopoiesis in adults?
Flat bones and metaphysics-cancellous bone.
What is responsible for controlling hematopoiesis?
Cytokines, hormones, growth factors.
What are the ways you can evaluate bone marrow? (6)
– peripheral blood: smear, CBC – flow cytometry – molecular analysis (PCR) – aspirates – core biopsies – Grossduring necropsy
In which of the below will you see you red bone marrow?
A. One day old calf
B. Two month old calf
C. One-year-old cow
A. One day old calf
And B. Two month old calf
But B will be less red because of the animal getting more mature.
What is the point of bone marrow biopsy?
The bone marrow biopsy is indicated in persistent hematologic abnormalities that are unexplainable based on clinical findings and examination of blood.
What Bone marrow biopsy confirming characterize?
Hematopoietic Hypoplasia, cell density, celldistribution, Marrow architecture
Where do you want to take your core bone marrow biopsies from? (3 best sites)
Humerus (greater tubercle), Ilium crest, femur
Why might you see an increase in red Marrow appearance? (3)
– increased demand for red blood cells (erythroid hyperplasia)
– increased demand for leukocytes (myeloid hyperplasia)
– neoplasia erythroid or myeloid (leukemia)
How long will it take before you see changes in the marrow stimulation due to an increased demand for red blood cell? (KNOW THIS)
3weeks
How long does it take for red blood cell production to increase? Will you see evidence of regeneration on the CBC before you see gross changes in the red marrow? (KNOW BOTH ANSWERS)
It will take about 4 to 5 days. And you will see evidence of regeneration on the CBC before you see the gross changes in the red marrow.
What are the 2 diseases that can cause an increase in white color of the bone marrow?
Lymphoproliferative diseases (more common) myeloproliferative diseases (less common)
Give some examples of lymphoproliferative diseases and myeloproliferative diseases.
Lymphoproliferative: lymphoma, lymphocytic leukemia
myeloproliferative: myeloid leukemia, is the acidic sarcoma, multiple myeloma, metastases
What are the three types of etiologies for bone marrow diseases?
Radiation, chemical, infections
What type of infections can cause bone marrow diseases? (7)
What are the two major classifications of osteomyelitis?
Bacterial osteomyelitis and fungal osteomyelitis
What is the one way you can have a congested spleen on necropsy when the dog was not sick or ill?
The barbiturates used in euthanasia.
What are the functions of spleen? (5)
– important in defense against blood-borne pathogens
– filters blood: reduce abnormal or aged RBCs
– stores hemosiderin
cash major hematopoietic organ in fetus and neonates
– reservoir for RBCs and platelets (horses, dogs, and cats)
What are the four degenerative diseases of the spleen?
– Senile atrophy (mainly in old dogs and horses)
– Siderotic plaques/Gamma Gandy bodies (GGB only in dogs)
– amyloidosis
– splenic rupture
What is Emily this is commonly secondary to?
Chronic inflammation
In what animal(s) do you most often see a splenic rupture?
What is the primary cause?
– Dogs and cats
– trauma
*Can be seen secondarily to splenomegaly or splenic neoplasia.
Whether the two types of splenic enlargement?B
Diffuse or nodular
What are the causes of a diffuse splenic enlargement?
Congestion, cell proliferation/infiltrate, accumulation of extracellular material
What are the causes of a nodular splenic enlargement?
Neoplasia or non-neoplastic
Where the visual differences with splenomegaly? (2)
You have a bloody spleen or a meaty spleen
What are the visual differences between a bloody spleen and a meaty sleep?A
Bloody: swollen margins, dark red, uses blood on section, congestion.
Meaty: swollen margins, often dark red, bulge on cut surface (rubbery), cellular infiltrates.
What are the causes of splenomegaly (bloody spleen)? (4)O
Septicemia (anthrax (cow), salmonella (horse)), acute hemolytic anemia, splenic torsion, barbiturate euthanasia
What are the causes of splenomegaly (meaty spleens)? (7)
Septicemia (Salmonella), hemolytic disease, lymphoma, mast cell neoplasia, histocytic sarcoma, granulomatous disease (histoplasmosis), amyloidosis
What are the three causes of splenic congestion?
Barbiturate – euthanasia
septic shock – endotoxemia
– splenic torsion/venous blockage