E1. Liver Flashcards
look at slides/skipped 19-22, 34, 38-41, 45, 53-54, 60, 62-63, 71-74, 78, 92-93, 97-98, 103, 108-109, 114-116, 118-138, 141-142, 146-163, 168-174, 177-181, 183-184, 190, 192, 195-197, 203-204, 214, 216-217, 219
pics slide: 10-14, 26, 29-33, 36, 42-43, 46-48, 50-52, 55-57, 66, 70, 76-77, 79-80, 84-88, 94-96, 106-107, 110, 117, 140, 144-145, 173, 180, 185, 191, 193-194, 198-201, 205, 218, 220-221
look at them
____ = Specific dz.’s sure to be on exam LOOK AT!!!!!!!!!!!!!!!!!!!
What is the percent body weight that the liver accounts for in carnivores, omnivores, and herbivores?
Carnivores: 3 to 4%
omnivores: 2%
herbivores: 1%
What percent of cardiac output does the liver get?
25% (67% portal vein, 33% hepatic artery)
Of the three zones which zone gets the most blood? Which gets the least?
Zone one
zone three
What is approximately 80% of the liver mass?
Hepatocytes
What are other names for stellate cells? What do they do?
Lipocytes, Ito cells.
produce and maintain intracellular matrix and store vitamin A.
What are Kupfer cells, and what do they do?
They are regional macrophages, and participate in immune and regenerative response.
What are the functions of the liver? (7)
– Bilirubin metabolism
What percent of the parenchyma in the liver needs to be injured before you see clinical signs?
Approximately 75%
What liver enzymes can be used as biomarkers for liver injury?
(AST, ALT, LDH, alkaline phosphatase, gamma-glutamyl transpeptidase)
What can cause liver atrophy? (4)
– Increased catabolism
What percent of the liver can regenerate within a week?
60%
What can differentiate into hepatocytes or bile duct epithelium?
Oval (stem) cells
What are the three things needed for liver regeneration?
Intact framework, good blood supply, patent bile ducts.
What are the three general responses of liver to injury?
Regeneration parenchyma, replacement of fibrosis, or biliary hyperplasia.
What happens to the liver with fibrosis?
How significant is this?
You’ll see an increased amount of connective tissue within it.
Significance depends upon the facts on normal hepatic function and type of collagen.
What can cause white spotted the liver in a pig? (slide 31)
Ascaris suum
What is cirrhosis?
Is regeneration that can result in hepatocellular nodular proliferation, fibrosis and impaired blood and bile flow. Usually seen in chronic injury.
What are the three types of liver degeneration and necrosis?
Random (single cell, multifocal piecemeal necrosis)
Zonal
Massive
Define zonal necrosis. Give some examples. (4)
Areas within hepatic lobule or acini are affected. – centrilobular – midzonal –periportal –bridging
What is one of the most common causes of the massive hepatic necrosis?
Hepatosis dietetica of swine.
What is Hepatitis dietetica associated with?
Generation of free radicals and deficiency of vitamin E/selenium.
What breeds are predisposed to congenital polycystic liver disease?
What is this disease?
Why might an animal die?
The breeds are:cair Terriers, West Highland White Terriers, and Persian cats.
The disease is multiple cysts located on the liver and kidney.
Animals may die due to liver or renal failure.
What are the five types of circulatory disturbances?
Congestion, infarction/ischemia (very rare), thrombosis, congenital portosystemic shunts, telangiectasis.
What would you expect to see with the liver in acute congestion?
Slight enlargement, and prominent reticular pattern due to congestion of centrilobular areas.
What will your liver look like with chronic passive congestion?
Nutmeg liver
What is another name for hepatic vein thrombosis?
Budd-chiari syndrome
What characterizes hepatic vein thrombosis?
Hepatomegaly, ascites, and abdominal pain.
What are the probable causes for hepatic vein thrombosis?
Conditions producing thrombotic tendencies or sluggish flow such as myeloproliferative disorders, infections, trauma and neoplasia.
*It is caused by thrombosis of the hepatic vein and the adjacent inferior vena cava