Dyslipidaemia

Question 1

What class of drugs MOA is to inhibit HMG-COA reductase?

Answer 1

Statins.

Question 2

List the 3 stages of statin induced myopathy.

Answer 2

1. Myalgia (muscle aches and pains)= reversible.
2. Myositis (inflammation to muscle cells, more damage to muscle cells)= sometimes reversible.
3. Rhabdomyolysis (muscle cell death)= irreversible.

Question 3

Name one sign/symptom of rhabdomyolysis and its mechanism.

Answer 3

Dark urine due to the increase in creatine kinase and myoglobin which is a sign of muscle death. This can also damage the kidney and is life threatening.

Question 4

What drug class would a statin be combined with if a patient had a high cholesterol diet?

Answer 4

Ezetimibe as its MOA is to reduce the absorption of cholesterol from the diet.

Question 5

Why may the combination of ezetimibe and a statin be problematic?

Answer 5

Increases the risk of muscle issues such as statin induced myopathy.