Anti-psychotics

Question 1

List some negative symptoms associated with Schizophrenia.

Answer 1

Depressive like symptoms: lowered mood, low motivation.

Question 2

List some positive symptoms associated with Schizophrenia.

Answer 2

Psychosis, delusions, hallucinations.

Question 3

List the 2 classes of anti-psychotics.

Answer 3

Typical and atypical.

Question 4

What is the MOA of Haloperidol (typical anti-psychotic)?

Answer 4

Blocks D2 receptors, blocks dopaminergic response in the mesolimbic pathway.

Question 5

List the main ADRs and the receptors responsible for Haloperidol (typical anti-psychotic).

Answer 5

D2 receptor block: muscle rigidity, clonus, tremor, bradykinesia.

Muscarinic Receptor block: anti-cholinergic effects: dry mouth, constipation, urinary retention.

Alpha 1 receptor block: vasodilation, orthostatic hypotension, reflex tachycardia.

H1 histamine receptors: sedation, hunger, weight gain.

Question 6

What pathway does Risperidone (atypical anti-psychotic) act on?

Answer 6

Mesocortical pathway, blocking 5-HT2 receptors.