Anti-coagulants

Question 1

What enzyme does Warfarin inhibit?

Answer 1

VKORC (vitamin k epoxide reductase).

Question 2

What clotting factors does Warfarin inhibit.

Answer 2

Clotting factors 2,7,9 and 10.

Question 3

Explain Warfarin’s indirect MOA.

Answer 3

Warfarin inhibits the enzyme VKORC which activates vitamin K which reduces the production of clotting factors.

Question 4

True or False: Warfarin undergoes genetic polymorphism?

Answer 4

True

Question 5

What foods cause a variability in Warfarin’s effectiveness?

Answer 5

Vitamin K rich foods such as green leafy vegetables.

Question 6

What D-D interaction increases the risk of bleeds with Warfarin and why?

Answer 6

NSAIDs and SAIDs due to the decrease in platelet aggregation which causes an increased risk of bleeds.

Question 7

What is the main ADR associated with Warfarin?

Answer 7

Bleeding (intracranial and GI).

Question 8

Do factor10a inhibitors have a direct or indirect MOA?

Answer 8

Direct- they directly inhibit factor 10a.

Question 9

t1/2 is a determining factor to Warfarin’s duration of action (true or false)?

Answer 9

False due to its indirect MOA.

Question 10

What class of drug is Rivaroxaban?

Answer 10

Factor 10a Inhibitor.