Diuretics Flashcards
1
Q
What part of the kidney does hydrochlorothiazide act at?
A
Distal convoluted tubule
2
Q
What drug class blocks the Na+Cl- symporter at the distal convoluted tubule?
A
Thiazide diuretics
3
Q
Name some short term effects for thiazide diuretics use.
A
Increased natriuresis, increased diuresis, decreased blood volume, decreased BP
4
Q
Name some long term effects for thiazide diuretics use.
A
Depletion of Na+, decreased sensitivity to vasopressin, decreased vasoconstriction.
5
Q
What type of diuretic has a high ceiling effect?
A
Loop diuretics (furosemide)
6
Q
What type of diuretic has a low ceiling effect?
A
Thiazide diuretics
7
Q
Name the 2 MOA for K+ Sparing Diuretics
A
Mineralocorticoid receptor antagonists, Na+ channel blockers.
