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Final Pharamcology > drugs_anti HIV > Flashcards

drugs_anti HIV Flashcards

(65 cards)

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1
Q

Zidovudin

A

Antiviral drug_HIV

Neucleosides

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2
Q

Lamivudine

A

Antiviral drug_HIV

Nucleosides (NRTIs)

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3
Q

Zidovudine + Lamivudine (Combivir)

A

given after accidental needle stick

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4
Q

Efavirenz

A

Antiviral drug_HIV

Nonnucleosides (NNRTIs)

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5
Q

Atazanavir

A

Antiviral drug_HIV

Protease inhibitor prevent formation of new viral particles

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6
Q

Fosamprenavir

A

Antiviral drug_HIV

Protease inhibitor; prodrug of amprevavir

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7
Q

Enfuvirtide

A

Antiviral drug_HIV

Fusion inhibitor block the binding of HIV to CD4 lymphocytes receptors that is required for HIV to enter cells

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8
Q

Raltegravir

A

Antiviral drug_HIV

Integrase inhibitor prevent integration of viral DNA into the DNA of the infected cells

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9
Q

2 RT inhibitor + 1 protease inhibitor

A

most effective tx of HIV

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10
Q

Amantadine

A

Antiviral_Influenza

Influenza type A infection prevention and treatment

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11
Q

Zanamivir

A

Antiviral drug_Neuraminidase inhibitors

Influenza A and B infection prevention and treatment

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12
Q

Acyclovir

A

Antiviral_Herpes
Herpes simplex type 1 and 2 (HSV-1, HSV-2)Varicella zoster virus (VZV), Epstein-Barr virus (EBV), Cytomegalovirus (CMV)- mono
*TOPICAL, IV, ORALLY for herpes infections

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13
Q

Foscarnet

A

Antiviral_herpes

approved for CMV retinitis, acyclovir-resistant HSV and VZV infections

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14
Q

Gancyclovir

A

Antiviral_herpes

Drug of choice for Cytomegalovirus infections

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15
Q

Aedefovir

A

Antiviral_hepatic viral

Hep B virus

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16
Q

Tenofovir

A

Antiviral_hepatic viral

Hep B virus

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17
Q

Pegylated interferon

A

Antiviral_hepatic viral
Hep B virus
inhibit viral RNA translation

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18
Q

Lamivudine

A

Antiviral_hepatic viral
Hep B virus
inhibitor of HBV DNA polymerase and HIV reverse transcriptase

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19
Q

Pegylated interferon alpha-2a

A

Antiviral_hepatic viral

Hep C infection

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20
Q

Pegylated interferon alpha-2b

A

Antiviral_hepatic viral

Hep C infection

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21
Q

Ribavirin

A

Antiviral_hepatic viral

Hep C infection

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22
Q

Cyclophosphamide

A

Anticancer drug

Most commonly used alkylating agent

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23
Q

u/e Cyclophosphamide

A

hemorrhagic cystitis

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24
Q

6-mercaptopurine

A

Anticancer drug

Antimetabolites

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25
5-flurouracil
Anticancer drug | Antimetabolites
26
Methotrexate
Anticancer drug Antimetabolites Psoriasis, severe active rheumatoid arthritis in addition to whole variety of cancers*administered intrathecally
27
Doxorubicin
Anticancer drug | Antibiotics
28
u/e Doxorubicin
Cardiotoxicity, alopecia and bone marrow depression
29
Bleomycin
Anticancer drug | Antibiotics
30
u/e Bleomycin
fatal pulmonary fibrosis | *extreme caution- preexisting history of lung disease
31
Plicamycin
Anticancer drug Antibiotics tx. Life-threatening hypercalcemia associated with malignancy
32
Vincristine
Anticancer drug | Microtubule inhibitor
33
u/e Vincristine
neurologic toxicity
34
Vinblastine
Anticancer drug | Microtubule inhibitor
35
u/e Vinblastine
bone marrow toxicity
36
Anastrozole
Anticancer drug Hormonal agent_aromatase inhibitor tx. estrogen-dependent breast cancer resistant to tamoxifen
37
Tamoxifen
Anticancer drug_Antiestrogen tx. estrogen receptor positive breast cancer * competitive antagonists of estrogen receptor
38
Flutamide
Anticancer drug_androgen receptor antagonist | tx. prostate cancer
39
Leuprolide
Anticancer drug_GnRh analog | tx. metastatic prostatic cancer
40
Rituximab
Anticancer drug_monoclonal antibodies | tx. chronic lymphocytic leukemia
41
Imatinib
Anticancer drug_other | tx. chronic myeloid leukemia
42
Geftinib
Anticancer drug_other | tx. non small cell lung cancer
43
Etoposide
Anticancer drug_other | tx. small cell carcinoma of the lungs
44
Cisplatin and Cardbaplatin
Anticancer drug_other | tx. testicular carcinoma, ovarian carcinoma, bladder carcinoma
45
Procarbazine
Anticancer drug_other | tx. Hodgkin's disease
46
L-asperginase
Anticancer drug_other | tx. childhood acute lymphocytic leukemia (ALL)
47
Bacille Calmette-Guerin (BGC) vaccine
TB vaccine, effective in treating small localized superficial urinary bladder carcinomaIntravesicular use Non-specific stimulant of the reticuloendothelial system
48
Asprin
Anti-inflammatory drug | Non selective inhibitors of cyclooxygenase
49
u/e Asprin
Reye syndrome if given in viral infections, especially in children
50
Diclofenac
Anti inflammatory drug | Non-selective inhibitors of cyclooxygenase
51
Indomethacin
Anti inflammatory drug Non selective inhibitors of cyclooxygenase tx. in patent ductus arteriosus (PDA) in new born babies
52
Celocoxib (Celebrax)
Anti inflammatory drug_selective COX-2 inhibitor | lower risk for GI bleeding, good for chronic use
53
u/e Celocoxib (Celebrex)
hypertention
54
Rofecoxib (Vioxx)
Anti inflammatory drug_selective COX-2 inhibitor | Withdrawn?
55
Acetaminophen
Anti inflammatory drug_analgesics | antipyretic, analgesic; weak anti inflammatory activity
56
Infliximab
Anti inflammatory drug_arthritis | tx. Crohn's disease
57
Methotrexate
Anti inflammatory drug | disease-modifying anti-rheumatic drug
58
D-Penicillamine
Anti inflammatory drug disease-modifying anti-rheumatic drug also tx. heavy metal poisoning, Wilson's disease
59
Aliopurinol
Goutreduce uric acid formation
60
Colchicine
tx. acute attack of gout
61
Probenecid
Gout drug_uricosuric drug | increase uric acid excretion by the KD
62
Cyclosprorine (CsA)
Immunosuppressive drug_selective inhibitors of cytokine production and fx Prevention and treatment of transplanted organ rejections
63
u/e Cyclosprorine (CsA)
nephrotoxicity, thromboembolism, neurotoxicity, seizure etc.
64
Azathioprine
Immunosuppressive drug_immunosuppressive antimetabolites | t-cells and b-cells are particularly affected by the inhibition of purine synthesis
65
Mycophenolate mofetil
Immunosuppressive drug_immunosuppressive antimetabolites | inhibits an enzyme that helps the growth of Tcells and Bcells

Final Pharamcology (8 decks)

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