Drugs to Tx Interstitial Lung Disease Flashcards
What glucocorticoid is used to treat interstitial lung disease?
Prednisone
When using prednisone you want to monitor patients for?
1) Hyperglycemia
2) Cushing’s syndrome
What is an immunosuppressive drug used in the treatment of interstitial lung disease?
Mycophenolate
What black box warning is associated with mycophenolate?
Increase risk of miscarriage in the first trimester of pregnancy
What drug is used to treat interstitial lung disease but should only be used by physicians whose knowledge and experience include the use of antimetabolite therapy because of the possibility of serious toxic reactions that can be fatal?
Methotrexate
Can methotrexate be used during pregnancy?
Its elimination is reduced in patients with?
What potentially fatal opportunistic infections may occur with its use?
1) No
2) Impaired renal fxn
3) Pneumocystis carinii pneumonia
What drug interaction with methotrexate can cause elevated and prolonged serum methotrexate levels, resulting in death from severe hematologic and GI toxicity?
NSAIDs
Oral antibiotics such as tetracycline, chloramphenicol, and nonabsorbable broad spectrum antibiotics, may have what drug interaction with methotrexate?
Decrease intestinal absorption of methotrexate
Penicillins have what drug interaction with methotrexate?
Reduce the renal clearance
What drug used to treat interstitial lung disease is an immunosuppressive antimetabolite and is available in tablet form for oral administration?
Azathioprine
What black box warning is associated with azathioprine?
It increases the risk of malignancy
What drug used to treat interstitial lung disease is a kinase inhibitor indicated for the treatment of idiopathic pulmonary fibrosis?
Nintedanib
Co-administration of what drugs may increase Nintedanib exposure?
P-gp and CYP3A4 inhibitors
