Drugs to Tx Influenza

Question 1

What is the MOA of Neuraminidase Inhibitors?

Answer 1

Stops viral reproduction by preventing neuraminidase from cleaving sialic acid on glycoproteins on human cells

Question 2

What is the oral neuraminidase inhibitor oseltamivir is indicated for?

Answer 2

Influenza A and B infection patients that have been symptomatic for no more than 48 hours

Question 3

Oseltamivir is contraindicated in what adult patients?

Answer 3

Those with end-stage renal disease

Question 4

Oseltamivir is contraindicated in what pediatric patients?

Answer 4

1) Children younger than 2 weeks of age

2) Prophylaxis in children younger than 1 year of age

Question 5

When can Oseltamivir be used as a substitute for early influenza vaccination?

Answer 5

Never

Question 6

What warning is issued with Oseltamivir in terms of affecting the influenza vaccine effectiveness?

Answer 6

Do not give live influenza vaccine (intranasal) within 2 weeks before, or 48 hours after oseltamivir is given

Question 7

What is Oseltamivir activated by?

What other drug inhibits this activation?

Answer 7

1) Carboxylesterase 1 isoenzyme (CES1)

2) Clopidogrel

Question 8

What is a inhalation neuraminidase inhibitor which is approved for treatment of acute uncomplicated illness due to influenza A and B virus?

Answer 8

Zanamivir

Question 9

What population is zanamivir indicated for?

Answer 9

Adults and pediatric patients aged 7 and up who have been symptomatic for no more than 2 days

Question 10

What conditions is zanamivir contraindicated for?

Answer 10

1) Seizures

2) Any lung disease

Question 11

Does zanamivir have the same guidelines as oseltamivir in terms of use with the influenza vaccine?

Answer 11

Yes

Question 12

CDC recommends women in any trimester of their pregnancy who have a suspected or confirmed influenza infection receive prompt antiviral therapy with?

Answer 12

Oseltamivir or zanamivir

Question 13

Zanamivir is almost exclusively eliminated from the body via?

Answer 13

Kidney

Question 14

What is a intravenous neuraminidase inhibitor which is approved for treatment of acute uncomplicated influenza?

Answer 14

Peramivir

Question 15

Peramivir is indicated for what population?

Answer 15

Patients 18 years and older who have been symptomatic for no more than 2 days

Question 16

What warning is given with peramivir?

Answer 16

May increase risk of hallucinations, delirium and abnormal behavior

Question 17

What is a polymerase acidic endonuclease inhibitor used in the treatment of acute uncomplicated influenza?

Answer 17

Baloxavir

Question 18

Baloxavir is indicated for what population?

Answer 18

Patients 12 years of age and older who have been symptomatic for no more than 48 hours

Question 19

What is indicated for the prophylaxis and treatment of signs and symptoms of infection caused by various strains of influenza A virus and is also indicated in the treatment of parkinsonism?

Answer 19

Amantadine

Question 20

The lowest reported acute lethal dose of amantadine was?

Answer 20

1 gram

Question 21

What patient population is amantadine contraindicated for?

Answer 21

Those diagnosed with depression or with history of suicide attempts

Question 22

Dosage of amantadine should be reduced in what patient population?

Answer 22

Those with renal disease