Drugs test 3

Question 1

levodopa MOA

Answer 1

converted to dopamine by DOPA decarboxylase (in both the periphery and CNS) to act on D1 and D2 receptors

Question 2

levodopa SAE

Answer 2

Nausea, arhythmia, orthostatic hypotension (peripheral toxicity)

Neuropsychiatric symptoms (central toxicity)

Question 3

carbidopa MOA

Answer 3

peripheral DOPA decarboxylase inhibitor, which increases the bioavailability of levodopaand decreases the peripheral toxicities of levodopa

Question 4

catechol-O-methyltransferase (COMT) MOA

Answer 4

converts levodopa to 3-OMD in the periphery and 3-MT in the CNS (neutralizes levodopa)

Question 5

tolcapone MOA

Answer 5

peripheral and central COMT inhibitor (increases bioavailability of levodopa)

Question 6

tolcapome SAE

Answer 6

hepatotoxicity

Question 7

entacapone MOA

Answer 7

peripheral COMT inhibitor (increases bioavailability of levodopa)

Question 8

amantadine MOA

Answer 8

increases dopamine synthesis/release and inhibits uptake

Question 9

pramipexole

Answer 9

D3 receptor agonist

treat restless leg syndrome

Question 10

ropinirole

Answer 10

D2 receptor agonist

treat restless leg syndrome

Question 11

ropinirole SAE

Answer 11

may enhance impulse control disorders (gambling, shopping, hypersexuality)

Question 12

selegiline MOA

Answer 12

monoamine oxidase B inhibitor (increases dopamine levels in CNS)

Question 13

trihexyphenidyl MOA

Answer 13

M1 antagonist

improves tremor and rigidity

Question 14

Benztropine MOA

Answer 14

M1 antagonist

improves tremor and rigidity

Question 15

haloperidol MOA and uses

Answer 15

D2 receptor antagonist

chorea, psychosis, irritability

Question 16

fluphenazine MOA and uses

Answer 16

D2 receptor antagonist

chorea, psychosis, irritability