anti-platelet/anticoagulation drugs (test 2) Flashcards

1
Q

Heparin

A

unfractionated heparin

binds to antithrombin III –> bind Xa and IIa

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2
Q

LMWH

A

low molecular weight heparin (smaller than heparin)

binds to antithrombin III –> bind Xa

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3
Q

fondaparinux

A

binds to antithrombin III –> bind Xa

higher affinity to antithrombin III compared to LMWH

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4
Q

bivalirudin

A

direct thrombin inhibitor

used to reverse HIT

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5
Q

argatorban

A

direct thrombin inhibitor

used to reverse HIT

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6
Q

dabigatran

A

direct thrombin inhibitor

used to reverse HIT

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7
Q

rivaroxaban

A

direct Xa inhibitor

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8
Q

apixaban

A

direct Xa inhibitor

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9
Q

warfarin

A

vitamin K epoxide reductase (VKOR) inhibitor

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10
Q

clopidogrel

A

antiplatelet agent

ADP (P2-Y12) receptor antagonist

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11
Q

ticgrelor

A

antiplatelet agent

ADP (P2-Y12) receptor antagonist

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12
Q

prasugrel

A

antiplatelet agent

ADP (P2-Y12) receptor antagonist

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13
Q

aspirin

A

antiplatelet agent

irreversibly acetylates COX-1 and COX-2 (for the life of the platelet)

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14
Q

abciximab

A

GPIIb/IIIa receptor antagonist

monoclonal antibody

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15
Q

tirofiban

A

GPIIb/IIIa receptor antagonist

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16
Q

epitifibatide

A

GPIIb/IIIa receptor antagonist

17
Q

dipyridamole

A
antiplatelet
phosphodiesterase inhibitor (increases cAMP in platelet)
18
Q

cilostazol

A
antiplatelet
phosphodiesterase inhibitor (increases cAMP in platelet)