Drugs for Rheumatoid Arthritis Flashcards
Classes of drugs used in R.A.
NSAIDS, Glucocorticoids, and DMARDs
Indications of NSAIDs in R.A.
Reduce pain and inflammation
Indications of Oral corticoids in R.A.
Relieve joint symptoms and control systemic manifestations; chronic use may cause many complications
True or False: NSAIDs and corticosteroids do not prevent disease progression or joint destruction.
True
Which group of drugs used in R.A. can reduce or prevent joint damage?
DMARDs
MOA of DMARDs
Delay and possible stop disease progression, but no immediate analgesic effects
Time-line of DMARD effects
6 weeks - 6 months
First DMARD usually prescribed for mild, moderate, or severe R.A.
Methotrexate
When are biologic DMARDs used?
Moderate to severe R.A.
AE of Methotrexate in R.A. use
Minimized because doses are much lower than when used for chemotherapy
Used in combination therapy with Methotrexate for R.A. in patients who do not respond to Methotrexate alone
Leflunomide; as effective as Methotrexate at reducing disease activity and progression
Least toxic of all DMARDs
Hydroxychloroquine
Least effective as mono therapy for R.A.; usually combined with Methotrexate and Sulfasalazine
Hydroxychloroquine
Moderately effective against mild R.A. and may take 3-6 months to show effects
Hydroxychloroquine
Sulfa drug use in R.A.; benefits show after 2-3 months
Sulfasalazine