Antineoplastics- Antimetabolites Flashcards
Oral prodrug of 5-Fluorouracil catalyzed by thymidine phosphorylase
Capecitabine
DOC for childhood ALL
6-mercaptopurine (6-MP)
AE: Renal damage due to crystal deposits in tubules
Methotrexate
Causes Hand/Foot Syndrome
5-Fluoruracil
Prodrug that inhibits Ribonucleotide Reductase (RNR) and causes chain termination
Gemcitabine
No drug interaction with Allopurinol
6-thioguanine (6-TG)
Metabolized by Xanthine Oxidase and Thiopurine Methyltransferase
6-Mercaptopurine
Not useful in patients with HGPRT deficiency (Lesch Nyhan Syndrome)
6-mercaptopurine
Useful for colorectal cancer
Capecitabine and 5-Fluorouracil
Useful for Pancreatic cancer
Gemcitabine
Catabolized by Dihydropyrimidine dehydrogenase; deficiency causes Life-threatening diarrhea, myelosuppression, neurotoxicity
5-Fluorouracil
Converted to polyglutamates to inhibit DHF Reductase
Methotrexate
Used with Methotrexate to rescue THF to prevent bone marrow toxicity
Leucovorin (folinic acid)
Combination therapy for colorectal cancer
5-Fluorouracil + Leucovorin
First line treatment for metastatic colorectal cancer
Capecitabine