Antineoplastics- Antimetabolites Flashcards

1
Q

Oral prodrug of 5-Fluorouracil catalyzed by thymidine phosphorylase

A

Capecitabine

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2
Q

DOC for childhood ALL

A

6-mercaptopurine (6-MP)

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3
Q

AE: Renal damage due to crystal deposits in tubules

A

Methotrexate

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4
Q

Causes Hand/Foot Syndrome

A

5-Fluoruracil

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5
Q

Prodrug that inhibits Ribonucleotide Reductase (RNR) and causes chain termination

A

Gemcitabine

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6
Q

No drug interaction with Allopurinol

A

6-thioguanine (6-TG)

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7
Q

Metabolized by Xanthine Oxidase and Thiopurine Methyltransferase

A

6-Mercaptopurine

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8
Q

Not useful in patients with HGPRT deficiency (Lesch Nyhan Syndrome)

A

6-mercaptopurine

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9
Q

Useful for colorectal cancer

A

Capecitabine and 5-Fluorouracil

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10
Q

Useful for Pancreatic cancer

A

Gemcitabine

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11
Q

Catabolized by Dihydropyrimidine dehydrogenase; deficiency causes Life-threatening diarrhea, myelosuppression, neurotoxicity

A

5-Fluorouracil

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12
Q

Converted to polyglutamates to inhibit DHF Reductase

A

Methotrexate

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13
Q

Used with Methotrexate to rescue THF to prevent bone marrow toxicity

A

Leucovorin (folinic acid)

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14
Q

Combination therapy for colorectal cancer

A

5-Fluorouracil + Leucovorin

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15
Q

First line treatment for metastatic colorectal cancer

A

Capecitabine

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16
Q

AE: HUS and TTP

A

Gemcitabine

17
Q

Can be used topically for ketatoses and Basal Cell Carcinoma

A

5-Fluorouracil

18
Q

Antimetabolites are cell cycle specific for which phase?

A

S-phase

19
Q

Decreases intracellular GMP to inhibit DNA synthesis

A

6-thioguanine

20
Q

Hypoxanthine analog

A

6-mercaptopurine

21
Q

Converted TIMP to inhibit de novo purine synthesis

A

6-mercaptopurine

22
Q

Dose must be reduced if given with Allopurinol

A

6-mercaptopurine

23
Q

If deficient in Thiopurine Methyltransferase, which 2 drugs would require a lesser dose?

A

6-mercaptopurine and 6-thioguanine

24
Q

Neurotoxicity with Intrathecal administration

A

Methotrexate

25
Q

Competitively inhibits alpha and beta DNA Polymerase and inserts itself into nucleic acid

A

Cytarabine

26
Q

Only useful for hematologic malignancies; not useful against solid tumors

A

Cytarabine

27
Q

Folate Analog

A

Methotrexate

28
Q

Purine Analogs

A

6-Mercaptopurine and 6-Thioguanine

29
Q

Pyrimidine Analogs

A

5-Fluorouracil, Capecitabine, Deoxycytidine Analogs (Gemcitabine and Cytarabine)