Antineoplastics - Microtubule Inhibitors Flashcards
Which phase of the cell cycle is inhibited in Microtubule Inhibitors?
M phase
MOA of Vinblastine and Vincristine
Vinca Alkaloids; Bind beta tubulin to prevent microtubule formation, arresting cells in M phase
MOA of Paclitaxel and Docetaxel
Taxanes; Bind beta tubulin at different site than Vinca Alkaloids to promote microtubule polymerization but inhibit depolymerization ==> activates apoptosis
MOA of Etoposide and Teniposide
Inhibit Topoisomerase II at late S phase and early G2
Topoisomerase I inhibitors, cutting 1 strand of DNA
Topotecan and Irinotecan
Bone marrow sparing but causes peripheral neuropathy
Vincristine
Vinca Alkaloid, potent vesicant
Vinblastine
Epipodophyllotoxin indicated for refractory childhood ALL
Teniposide
Vinca Alkaloid that causes bone marrow suppression (dose-limiting effect)
Vinblastine
Indications for Vincristine
hematologic malignancies and pediatric tumors
AE: neurotoxicity with peripheral neuropathy, Paralytic Ileus, Optic Atrophy, SIADH
Vincristine
fecal excretion via hepatobiliary route
Taxanes; dose reduction in hepatic dysfxn
Camptothecins
Topoisomerase I Inhibitors: Topotecan, Irinotecan
Microtubule Inhibitors
Vinca Alkaloids and Taxanes
Taxanes
Paclitaxel, Docetaxel
Epipodophyllotoxins
Etoposide, Teniposide
2nd line therapy for advanced Ovarian Cancer and SCLC
Topotecan
combined with 5-Fluorouracil and Leucovorin to treat metastatic colorectal cancer
Irinotecan
Albumin-bound form of Paclitaxel that does not cause hypersensitivity
Abraxane
Used as pretreatment for Paclitaxel
Dexamethasone, Diphenyhydramine, and H2 blocker
2nd line therapy in advanced breast cancer and NSCLC
Docetaxel
Used as pretreatment for Docetaxel to prevent fluid retention
Dexamethasone
Taxane that causes hypersensitivity and peripheral neuropathy
Paclitaxel
Epipodophyllotoxin indicated for testicular cancer and SCLC
Etoposide
