Antimicrobials - Drugs Affecting Nucleic Acid Synthesis Flashcards
2nd Generation Fluoroquinolones
Ciprofloxacin
1st Generation Fluoroquinolones
Nalidixic Acid
4th Generation Fluoroquinolones
Gemifloxacin and Moxafloxicin
3rd Generation Fluoroquinolones
Levofloxacin
MOA of Fluoroquinolones
Enter bacteria through porins and irreversibly interfere with Topoisomerase II (gyrase) and Topoisomerase IV to inhibit DNA replication
Indications for 2nd Generation Fluoroquinolones
Traveler’s diarrhea, P.aeruginosa in CF patients
Indications for 4th Generation Fluoroquinolones
Monotherapy for CAP
Indications for 1st Generation Fluoroquinolones
Uncomplicated UTIs
Indications for 3rd Generation Fluoroquinolones
CAP, Prostatitis (E.coli)
What can adversely affect Fluoroquinolone absorption?
Divalent cations, milk, antacids
AE of Fluoroquinolones
“Lones hurt bones” - Connective Tissue problems i.e. tendon rupture; QT prolongation with 3rd and 4th generation
Contraindications of Fluoroquinolones
Pregnancy, nursing mothers, age <18
Resistance to Fluoroquinolones
Mutations in Topoisomerase II or IV, efflux pumps
What are the Sulfonamides?
Sulfasalazine, Sulfamethoxazole, Sulfadiazine; structural analogs of PABA
Indications of Sulfasalazine
Inflammatory bowel disease