Antineoplastics - Antitumor Antibiotics Flashcards

1
Q

contains DNA binding region and iron-binding region; causes ROS formation and DNA strand breakage

A

Bleomycin, cell cycle specific

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2
Q

Causes pulmonary fibrosis due to low hydrolase activity

A

Bleomycin

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3
Q

DNA intercalation, Topoisomerase II inhibitor, alters membrane fluidity and ion transport, generates ROS through an iron-dependent enzyme mediated reduction

A

Anthracyclines

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4
Q

Cardiotoxicity: dilated cardiomyopathy associated with HF

A

Anthracyclines

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5
Q

Anthracycline used for AML but not solid tumors

A

Daunorubicin

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6
Q

Radiation Recall Rxn

A

Anthracyclines

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7
Q

iron-chelating agent given to reduce cardiotoxicity

A

Dexrazoxane

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8
Q

Antitumor antibiotic that causes flagellated skin hyperpigmentation

A

Bleomycin

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9
Q

Anthracycline with broad spectrum of activity

A

Doxorubicin

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10
Q

limited bone marrow suppression

A

Bleomycin

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11
Q

cell cycle non-specific antitumor antibiotics

A

Anthracyclines

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12
Q

causes pneumonitis and pulmonary fibrosis

A

Bleomycin

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