Antineoplastics - Antitumor Antibiotics Flashcards
contains DNA binding region and iron-binding region; causes ROS formation and DNA strand breakage
Bleomycin, cell cycle specific
Causes pulmonary fibrosis due to low hydrolase activity
Bleomycin
DNA intercalation, Topoisomerase II inhibitor, alters membrane fluidity and ion transport, generates ROS through an iron-dependent enzyme mediated reduction
Anthracyclines
Cardiotoxicity: dilated cardiomyopathy associated with HF
Anthracyclines
Anthracycline used for AML but not solid tumors
Daunorubicin
Radiation Recall Rxn
Anthracyclines
iron-chelating agent given to reduce cardiotoxicity
Dexrazoxane
Antitumor antibiotic that causes flagellated skin hyperpigmentation
Bleomycin
Anthracycline with broad spectrum of activity
Doxorubicin
limited bone marrow suppression
Bleomycin
cell cycle non-specific antitumor antibiotics
Anthracyclines
causes pneumonitis and pulmonary fibrosis
Bleomycin