Antivirals Flashcards
Neuraminidase Inhibitors
Oseltamivir and Zanamivir
Nucleotide/Nucleoside Analog used for Respiratory Infections
Ribavirin
Ion Channel Blockers
Amantadine
Drugs for Respiratory Infections
Neuraminidase Inhibitors, Nucleoside/Nucleotide Analog, Ion Channel Blockers
Interferon used for Hepatic infections
Interferon alpha
Nucleotide/Nucleoside Analogs used for Hepatic Infections
Lamivudine and Entecavir
Protease Inhibitors used for Hepatic Infections
Boceprevir and Telaprevir
Purine and Pyrimidine Analogs used for Herpes Infections
Ganciclovir, Acyclovir, Cidofovir, Penciclovir, Trifluridine, Foscarnet
MOA of Neuraminidase Inhibitors
Inhibit release of virus by inhibiting sialic acid (substrate for Neuraminidase)
MOA of Ribavirin
Inhibits GTP formation and prevents viral mRNA capping; Inhibits RNA-dependent RNA polymerase –> inhibiting viral protein synthesis
Contraindications of Ribavirin
Category X; must have -ve pregnancy test before and during treatment
Contraindications of Amantadine and Rimantadine
Category X and contraindicated in nursing; crosses BBB
MOA of Amantadine and Rimantadine
Uncoating Inhibitors; block viral M2 protein (H+ channel) needed for viral uncoating
Indications of Neuraminidase Inhibitors
Influenza A & B
PK/PD of Oseltamivir
Oral prodrug hydrolyzed in the liver
PK/PD of Zanamivir
Inhalation
Contraindications of Zanamivir
Asthma, COPD
AE of Zanamivir
Airway irritation
AE of Amantadaine
Hallucinations, ataxia, seizures; monitor in psych patients
Synthetic guanosine analog effective against RNA and DNA viruses
Ribavirin
Indications of Ribavirin
RSV, HCV (combined with IFN alpha), and Lassa Fever
Indications for Amantadine and Rimantadine
Influenza A only
AE of Ribavirin
Transient anemia, GI, CNS
MOA of Interferon alpha
Induces expression of proteins that inhibit RNA and DNA synthesis and viral infection
AE of Interferon alpha
Flu-like symptoms and mental depression
Nucleoside/Nucleotide Analog for Hepatic Infections that is found in monophosphate and triphosphate forms
Lamivudine
What does the triphosphate form of Lamivudine do?
Inhibits HBV and HIV Reverse Transcriptase
What does the monophosphate form of Lamivudine do?
Incorporated into DNA to cause chain termination