Drugs for Pain Control NSAIDS_April 30

Question 1

What system do NSAIDS work on?

Answer 1

Eicosanoid system

(Act on cox-1 and cox-2) to inhibit conversion of arachidonic acid to Prostaglandins)

-Prevents pain, swelling, vasodilation

Question 2

What is the main function of COX-1

Answer 2

(Constituitive)
Platelet aggregation
Vasodilation, protect mucosa of GI tract
Maintain kidney bloodflow

Question 3

What is the main function of COX-2?

Answer 3

-Forms prostaglandins
(Pain and inflammation)
-Inducible

Question 4

What functions do we use NSAIDS for?

Answer 4

• Analgaesic
• Anti-inflammatory
• Body temperature lowering

Question 5

What are the adverse effects of NSAIDS?

Answer 5

• GI: microbleeding, superficial ulcers
• Platelets: bleeding tendencies, abdominal problems
• Repiratory system: Asthma attack/rhinitis possibility
• Kidney: risk of failure
• Risk of myocardial infarction and hypertension
• Adverse pregnancy

Question 6

What are the contraindications of NSAIDS?

Answer 6

• Previous asthma
• Previous GI bleeding
• PRevious CV disease (hypertension, stroke)
• Previous kidney disease
• Elderly
• Pregnancy

Question 7

What drug interactions should you be aware of?

Answer 7

• Triple whammy (diuretics, ACEI)
• Potassium sparring diuretics
• Antihypertensive (negate effect)
• Blood thinners (increase effect)

Question 8

What are the effects of prostaglandins?

Answer 8

• Vasodilation
• Smooth muscle contraction
• GI inhibit mucous secretion

Question 9

What is the dosing regiment of ibuprofen?

Answer 9

• 400mg
• 4x a day
• 3 days