Antibiotics_Cephalosporin_March 19

Question 1

Is the spectrum of cephalosporins broader or narrower than penicillin?

Answer 1

Broader

Question 2

What is the risk of cross reactivity with cephalosporins and penicillins?

Answer 2

5-10% (lecture)

0.17-8.4% (Therapeutic guideline)

Question 3

Why do we not use cephalosporin first line?

Answer 3

-Higher risk of resistance

Question 4

What are the different generations of cephalosporin? What is the difference between each generation?

Answer 4

HIgher the generation the more the G- cover but less G+ cover

Gen1:

• Cephalexin (oral)
• Cephazolin (parenteral)

Gen 2:
-Cefaclor (oral)

-Rest are parenteral and I cbs writing them up