Drugs for Movement Disorders Flashcards
What the the Levodopa combinations?
- Levodopa + Carbidopa
- Levodopa + Carbidopa + Entacapone
What are the Levodopa combinations?
- Levodopa + Carbidopa
- Levodopa + Carbidopa + Entacapone
What are the 3 Monoamine Oxidase B Inhibitors?
Selegiline
Rasagiline
Safinamide
What are the 3 Monoamine Oxidase B Inhibitors?
Selegiline
Rasagiline
Safinamide
What are the 2 Catechol-O-Methyltransferase Inhibitors?
Tolcapone
Entacapone
What are the 2 Catechol-O-Methyltransferase Inhibitors?
Tolcapone
Entacapone
What are 2 Anticholinergic Drugs?
Benztropine
Trihexyphenidyl
What are 2 Anticholinergic Drugs?
Benztropine
Trihexyphenidyl
What are the 5 Dopamine Receptor Agonists?
Ropinirole Apomorphine Bromocriptine Pramipexole Rotigotine
What are the 5 Dopamine Receptor Agonists?
Ropinirole Apomorphine Bromocriptine Pramipexole Rotigotine
What is an agent used for Parkinson Disease with an unknown MOA?
Amantadine
What is an agent used for Parkinson Disease with an unknown MOA?
Amantadine
With Parkinson Disease, what type of neurons are lost in the Substantia Nigra?
Dopamine producing neurons are lost
==> Decreased Dopamine
Levodopa is the precursor for Dopamine. It is in the periphery and then crosses the BBB. What 2 enzymes can turn L-Dopa into 3-OMD and Dopamine in the PERIPHERY respectively?
COMT –> 3-OMD
DOPA Decarboxylase –> Dopamine
Levodopa is the precursor for Dopamine. It is in the periphery and then crosses the BBB. What 2 enzymes can turn L-Dopa into 3-MT and DOPAC in the BRAIN respectively?
COMT –> 3-MT
MAO-B –> DOPAC
What is the On/Off Phenomenon?
Switch between mobility and immobility in Levodopa treated patients near the end of a dose
What are treatment options for the On/Off Phenomenon? (3)
- Controlled release of Levodopa or intestinal gel infusion form
- Shorten interval between doses
- Add medication
If deep brain stimulation is performed for Parkinson Disease, in what 2 locations should it be done?
- Subthalamic nucleus
- Globus Pallidus Interna
What are the treatment options for Huntington Disease?
NONE – treat non-motor symptoms
With Restless Leg Syndrome, what should be checked and corrected first?
Treat iron deficient anemia if present
If Restless Leg Syndrome is present without anemia, what should the treatment be if there are no comorbidities?
Alpha 2 Delta Calcium channel ligand
If Restless Leg Syndrome is present without anemia but there are comorbidities like obesity/depression, what should the treatment be?
Dopamine Agonist
With an Essential Tremor, what are 2 first line agent options?
Propranolol
Primidone
With an Essential Tremor, what is a second line agent?
Botulinum Toxin A
What is a drug to treat ALS?
Riluzole
What is a drug to treat ALS?
Riluzole
What are 2 drugs available to treat Wilson Disease by decreasing copper?
Penicillamine
Potassium Disulfide
What are 2 drugs available to treat Wilson Disease by decreasing copper?
Penicillamine
Potassium Disulfide
If a patient has mild parkinson symptoms, what are the first 2 drug class options?
- MAO-B inhibitors
2. Amantadine
If a patient is less than 65 years old but has motor symptoms, what drug class should be considered for treatment?
Dopamine Receptor Agonists
