Drugs for Movement Disorders

Question 1

What the the Levodopa combinations?

Answer 1

• Levodopa + Carbidopa

- Levodopa + Carbidopa + Entacapone

Question 2

What are the Levodopa combinations?

Answer 2

• Levodopa + Carbidopa

- Levodopa + Carbidopa + Entacapone

Question 3

What are the 3 Monoamine Oxidase B Inhibitors?

Answer 3

Selegiline
Rasagiline
Safinamide

Question 4

What are the 3 Monoamine Oxidase B Inhibitors?

Answer 4

Selegiline
Rasagiline
Safinamide

Question 5

What are the 2 Catechol-O-Methyltransferase Inhibitors?

Answer 5

Tolcapone

Entacapone

Question 6

What are the 2 Catechol-O-Methyltransferase Inhibitors?

Answer 6

Tolcapone

Entacapone

Question 7

What are 2 Anticholinergic Drugs?

Answer 7

Benztropine

Trihexyphenidyl

Question 8

What are 2 Anticholinergic Drugs?

Answer 8

Benztropine

Trihexyphenidyl

Question 9

What are the 5 Dopamine Receptor Agonists?

Answer 9

Ropinirole
Apomorphine
Bromocriptine
Pramipexole
Rotigotine

Question 10

What are the 5 Dopamine Receptor Agonists?

Answer 10

Ropinirole
Apomorphine
Bromocriptine
Pramipexole
Rotigotine

Question 11

What is an agent used for Parkinson Disease with an unknown MOA?

Answer 11

Amantadine

Question 12

What is an agent used for Parkinson Disease with an unknown MOA?

Answer 12

Amantadine

Question 13

With Parkinson Disease, what type of neurons are lost in the Substantia Nigra?

Answer 13

Dopamine producing neurons are lost

==> Decreased Dopamine

Question 14

Levodopa is the precursor for Dopamine. It is in the periphery and then crosses the BBB. What 2 enzymes can turn L-Dopa into 3-OMD and Dopamine in the PERIPHERY respectively?

Answer 14

COMT –> 3-OMD

DOPA Decarboxylase –> Dopamine

Question 15

Levodopa is the precursor for Dopamine. It is in the periphery and then crosses the BBB. What 2 enzymes can turn L-Dopa into 3-MT and DOPAC in the BRAIN respectively?

Answer 15

COMT –> 3-MT

MAO-B –> DOPAC

Question 16

What is the On/Off Phenomenon?

Answer 16

Switch between mobility and immobility in Levodopa treated patients near the end of a dose

Question 17

What are treatment options for the On/Off Phenomenon? (3)

Answer 17

• Controlled release of Levodopa or intestinal gel infusion form
• Shorten interval between doses
• Add medication

Question 18

If deep brain stimulation is performed for Parkinson Disease, in what 2 locations should it be done?

Answer 18

• Subthalamic nucleus

- Globus Pallidus Interna

Question 19

What are the treatment options for Huntington Disease?

Answer 19

NONE – treat non-motor symptoms

Question 20

With Restless Leg Syndrome, what should be checked and corrected first?

Answer 20

Treat iron deficient anemia if present

Question 21

If Restless Leg Syndrome is present without anemia, what should the treatment be if there are no comorbidities?

Answer 21

Alpha 2 Delta Calcium channel ligand

Question 22

If Restless Leg Syndrome is present without anemia but there are comorbidities like obesity/depression, what should the treatment be?

Answer 22

Dopamine Agonist

Question 23

With an Essential Tremor, what are 2 first line agent options?

Answer 23

Propranolol

Primidone

Question 24

With an Essential Tremor, what is a second line agent?

Answer 24

Botulinum Toxin A

Question 25

What is a drug to treat ALS?

Answer 25

Riluzole

Question 26

What is a drug to treat ALS?

Answer 26

Riluzole

Question 27

What are 2 drugs available to treat Wilson Disease by decreasing copper?

Answer 27

Penicillamine

Potassium Disulfide

Question 28

What are 2 drugs available to treat Wilson Disease by decreasing copper?

Answer 28

Penicillamine

Potassium Disulfide

Question 29

If a patient has mild parkinson symptoms, what are the first 2 drug class options?

Answer 29

1. MAO-B inhibitors

2. Amantadine

Question 30

If a patient is less than 65 years old but has motor symptoms, what drug class should be considered for treatment?

Answer 30

Dopamine Receptor Agonists