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NMSP > Drugs for Dementia > Flashcards

Drugs for Dementia Flashcards

1
Q

What are the 3 Acetylcholinesterase Inhibitors?

A
  1. Donepezil
  2. Rivastigmine
  3. Galantamine
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2
Q

What are the 3 Acetylcholinesterase Inhibitors?

A
  1. Donepezil
  2. Rivastigmine
  3. Galantamine
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3
Q

What is the NMDA Antagonist?

A

Memantine

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4
Q

What is the NMDA Antagonist?

A

Memantine

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5
Q

What is the Beta-Amyloid Monoclonal Antibody?

A

Aducanumab

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6
Q

What is the Beta-Amyloid Monoclonal Antibody?

A

Aducanumab

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7
Q

What do Acetylcholinesterase Inhibitors do?

A

Increase Ach concentrations at the synaptic cleft

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8
Q

What are some of the adverse effects associated with Donepezil?

A
  • Altered cardiac conduction

- Worsens PUD/COPD/Asthma/Bladder outflow obstruction

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9
Q

What drug can cause altered cardiac conduction, and can worsen PUD/COPD/Asthma/Bladder outflow obstruction?

A

Donepezil

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10
Q

Donepezil has no evidence that is improves long term outcomes and there is no response in up to 50% of patients. However, what do around 20% of patients show?

A

Larger than average response

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11
Q

How is Rivastigmine given?

A

24 hour transdermal patch

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12
Q

Galantamine also has effects where?

A

nAchR – unknown value

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13
Q

What is Memantine often combined with?

A

Acetylcholinesterase Inhibitor = Donepezil

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14
Q

Memantine has small adverse effects. What is 1 more severe one?

A

Skin hypersensivity

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15
Q

What occurs with abrupt discontinuation of Acetylcholinesterase Inhibitors and the NMDA Antagonist?

A

Altered mental status and mood changes

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16
Q

What is the adverse effect of Aducanumab?

A

Amyloid related imaging abnormalities

17
Q

For mild Alzheimer Disease, what should be given?

A

Acetylcholinesterase Inhibitor

18
Q

For moderate/severe Alzheimer Disease, what should be given?

A

Acetylcholinesterase Inhibitor +/- Memantine

19
Q

Memantine is used for what type of Alzheimer Disease?

A

Moderate to sever

20
Q

If the patient is not tolerating the medications, what should you do?

A

Switch to another Acetylcholinesterase Inhibitor

NMSP (28 decks)

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