Drugs for Dementia Flashcards
What are the 3 Acetylcholinesterase Inhibitors?
- Donepezil
- Rivastigmine
- Galantamine
What are the 3 Acetylcholinesterase Inhibitors?
- Donepezil
- Rivastigmine
- Galantamine
What is the NMDA Antagonist?
Memantine
What is the NMDA Antagonist?
Memantine
What is the Beta-Amyloid Monoclonal Antibody?
Aducanumab
What is the Beta-Amyloid Monoclonal Antibody?
Aducanumab
What do Acetylcholinesterase Inhibitors do?
Increase Ach concentrations at the synaptic cleft
What are some of the adverse effects associated with Donepezil?
- Altered cardiac conduction
- Worsens PUD/COPD/Asthma/Bladder outflow obstruction
What drug can cause altered cardiac conduction, and can worsen PUD/COPD/Asthma/Bladder outflow obstruction?
Donepezil
Donepezil has no evidence that is improves long term outcomes and there is no response in up to 50% of patients. However, what do around 20% of patients show?
Larger than average response
How is Rivastigmine given?
24 hour transdermal patch
Galantamine also has effects where?
nAchR – unknown value
What is Memantine often combined with?
Acetylcholinesterase Inhibitor = Donepezil
Memantine has small adverse effects. What is 1 more severe one?
Skin hypersensivity
What occurs with abrupt discontinuation of Acetylcholinesterase Inhibitors and the NMDA Antagonist?
Altered mental status and mood changes
What is the adverse effect of Aducanumab?
Amyloid related imaging abnormalities
For mild Alzheimer Disease, what should be given?
Acetylcholinesterase Inhibitor
For moderate/severe Alzheimer Disease, what should be given?
Acetylcholinesterase Inhibitor +/- Memantine
Memantine is used for what type of Alzheimer Disease?
Moderate to sever
If the patient is not tolerating the medications, what should you do?
Switch to another Acetylcholinesterase Inhibitor
