DRUGS FOR MI

Question 1

Antiplatelet agents

Answer 1

Aspirin, 300 mg orally (chewed and swallowed), is administered at once to a patient with suspected or definite MI.
+ Clopidogrel: Loading dose of 300 mg followed by maintenance dose of 75 mg daily (for at least 1 month).

Question 2

Analgesia

Answer 2

Intravenous morphine 2-10 mg

Question 3

Antiemetics

Answer 3

promethazine 25–50 mg slow i.v.
prevent opioid-induced
vomiting.

Question 4

Anticoagulants

Answer 4

Low-molecular-weight heparin or unfractionated heparin
-prevent reinfarction and thromboembolic complications.

Question 5

.Nitrates

Answer 5

Intravenous nitroglycerin for recurrent or persistent pain and to
treat LV failure

Question 6

Low flow oxygen therapy

Answer 6

(2–4 L/minute) if there is decreased oxygen
saturation.

Question 7

Reperfusion therapy:Primary percutaneous coronary intervention (PCI) or thrombolytic therapy.

Answer 7

Thrombolytic therapy: Streptokinase, alteplase, tenecteplase, reteplase or urokinase is used to restore coronary patency and reperfusion of infarcted area. glycoprotein IIb/IIIa inhibitors (tirofiban)

Question 8

β-Blockers:

Answer 8

carvedilol, metoprolol, bisoprolol should be administered during first 24 hours, helps in decreasing myocardial oxygen demand and reducing overall workload on heart.
*They prevent reinfarction, arrhythmias and reduce mortality.

Question 9

ACE inhibitors/arbs

Answer 9

administered early to improve ventricular function.

Question 10

Statins

Answer 10

atorvastatin) should be started (secondary prevention) to reduce atheromatous plaque formation, thrombotic events and reinfarction.

Question 11

Acidosis

Answer 11

intravenous sodium bicarbonate.