antimalarial Flashcards
Tissue scizontocidal agents
primaquine (on both forms), atovaquone and proguanil (on primary form)
Blood scizontocidal agents,rapid acting
chloroquine, artemisinin derivatives, quinine, mefloquine, atovaquone, amodiaquine, lumefantrine
Blood scizontocidal agents,slow acting
proguanil, pyrimethamine + Sulfadoxine, clindamycin used always with rapid acting agents
Gametocidal agents
artemisinin and primaquine (active against all species), chloroquine and quinine (vivax)
Drugs used for casual prophylaxis (pre-erythrocytic stage in the liver)
proguanil (P. falciparum)
Drugs used for suppressive prophylaxis,suppress the erythrocytic phase and prevent clinical attack
chloroquine, mefloquine doxycycline
Chloroquine sensitive Plasmodium vivax malaria
Chloroquine and primaquine
Chloroquine sensitive Plasmodium falciparum malaria
Chloroquine
Chloroquine resistant Plasmodium falciparum malaria
- Artesunate + sulfadoxine + pyrimathamine
- Artesunate + mefloquine
- Artemether + lumefantrine
- Arterolane + piperaquine
*Quinine+doxycycline+clindamycin
prophylaxis In areas with chloroquine resistant P. falciparum malaria
Mefloquine or doxycycline or atovaquone
For terminal prophylaxis (P. vivax and P. ovale to prevent relapse)
Primaquine is started shortly before or after the person leaves
the endemic area
casual prophylaxis
prevent infection by killing sporozoites on entry into host
suppressive prophylaxis
suppress erythrocytic phase n prevent malarial fever
clinical cure
act on rbc stages n terminate clinical attack
radical cure
eliminate both hepatic n erythrocytic stage of P.vivax
