Drugs 6.8

Question 1

Fluticasone

Answer 1

Asthma

Long term use decreases airway inflammation and mucous production

Question 2

Montelukast

Answer 2

or zafirlukast
asthma
leukotriene D4 receptor antagonist
increase airway caliber (block bronchospasm) and reduce mucosal inflammation

Question 3

Desmopressin

Answer 3

Von Willebrand Disease (AD def)

Increase Von Willebrand factor release from endothelial cells

Question 4

Haloperidol

Answer 4

High potency 1st generation anti-psychotic

Delirium

Question 5

Lorazepam

Answer 5

Short t1/2
Preferred if impaired hepatic fxn
Short term anxiety tx

Question 6

Azoles

Answer 6

Decrease ergosterol synthesis -> cell wall

CYP 450 inhibition

Question 7

Aminoglycosides

Answer 7

Gentamicin
Resistance- modifying enzymes- add chemical groups to abx before entry- decrease binding ability
Ototoxicity and nephrotoxicity

Question 8

Digoxin toxicity

Answer 8

Anorexia, NVD
Arrhythmias
Color vision alterations, fatigue, confusion, weakness

Question 9

Nystatin

Answer 9

Anti-fungal; topical
Binds ergosterol-> pores in membrane
Related to AmpB

Question 10

Trazodone

Answer 10

Sedating antidepressant
Tx insomnia assc with depression or antidepressant tx
Risk priapism

Question 11

Isoniazid

Answer 11

inhibits mycolic acid synthesis

SE: neurotoxicity, hepatotoxicity

Question 12

Phenoxybenzamine

Answer 12

Irreversible a1 and a2 antagonist

Question 13

Phentolamine

Answer 13

Reversible, competitive a antagonist

For catecholamine induced HTN crisis

Question 14

Doxorubicin

Answer 14

Cardiotoxicity- dilated cardiomyopathy

Question 15

Rituximab

Answer 15

CD20 + lymphoma

Question 16

Argatroban

Answer 16

Direct thrombin inhibitor

Tx HIT

Question 17

Mesna

Answer 17

Binds and inactivates toxic chemo metabolites

Prevent hemorrhagic cystitis