Brain cancers

Question 1

Glioblastoma multiforme

Answer 1

Adults, malignant, cerebral hemispheres
astrocytes-GFAP
pseudopalisading, pleomorphic tumor cells, central necrosis and hemorrhage

Question 2

Meningioma

Answer 2

Adults, benign, surface
Arachnoid cells
Spindle cells, whorled patter, psammoma bodies, calcifications

Question 3

Hemangioblastoma

Answer 3

Adults, cerebellum
capillaries
VHL

Question 4

Schwannoma

Answer 4

Adults, cerebellopontine angle
S-100+
Encapsulated, alternating, spindle cells (elongated regular nuclei)

Question 5

Oligodendroglima

Answer 5

Adults, frontal lobes

fried egg cells, chicken wire capillary, calcifications

Question 6

Pilocytic astrocytoma

Answer 6

Kids, posterior fossa/cerebellum
GFAP
Rosenthal fibers-eosinophilic corkscrew
Spindle cells w/ hair-like glial processes, microcysts

Question 7

Medulloblastoma

Answer 7

Kids, malignant, cerebellum
primitive neuroectoderm
Non-communicating hydrocephalus
Homer-Wright rosettes, small blue cells, hypercellular
CN VI palsy

Question 8

Ependymoma

Answer 8

Kids, 4th ventricle
ependymal cells
hydrocephalus, perivascular rosettes, rod-shaped blepharoplasts

Question 9

Craniopharyngioma

Answer 9

kids, remnants of Rathke pouch-supratentorial

calcification; cholesterol crystals in “motor oil” fluid

Question 10

Pinealoma

Answer 10

Parinaud syndrome (vertical gaze palsy)
obstructive hydrocephalus
precocious puberty in boys