Bug toxins

Question 1

Diphtheria

Answer 1

Inactivate elongation factor 2 via ribosylation

Question 2

Pseudomonas

Answer 2

Exotoxin A-inactivate EF-2

Question 3

Shigella

Answer 3

inactivate 60s ribosome-> mucosal damage

Question 4

EHEC

Answer 4

Inactivate 60s ribosome -> cytokine release

Question 5

ETEC- heat labile

Answer 5

increase cAMP-> Cl- secretion

Question 6

ETEC- heat stabile

Answer 6

Increase cGMP-> decrease reabsoption

Question 7

Anthrax

Answer 7

Edema toxin-increase cAMP
Lethal factor- zinc dependent protease, inhibits protein kinase signaling-> apoptosis
D-glutamate antiphagocytic capsule

Question 8

Cholera

Answer 8

increase cAMP-> Cl- secretion

Question 9

Pertussis

Answer 9

increase cAMP-> impair phagocytosis

Question 10

C. tetani

Answer 10

cleave SNARE proteins- prevent release of inhibitory neurotransmitters (GABA and gly)

Question 11

C. botulinum

Answer 11

cleave SNARE proteins- prevent release of stimulatory neurotransmitters (ACh)

Question 12

C. perfringens

Answer 12

alpha toxin- phospholipase/lecithinase- degrades tissue and membranes

Question 13

S. pyogenes

Answer 13

Streptolysin O- degrade cell membranes- lyse RBCs

Exotoxin A- superantigen

Question 14

S. aureus

Answer 14

TSST-1- bind MHC II and TCR- superantigen

Protein A-bind Fc

Question 15

Endotoxin

Answer 15

macrophage, complement, and tissue factor activation

Question 16

C. dif

Answer 16

Toxin A- recruit and activate neutrophils-> inflm

Toxin B- actin depolymerization-> cell death

Question 17

Staph scalded skin syndrome

Answer 17

Exfoliative exotoxins-> protease- cleave desmoglein

Question 18

Mening

Answer 18

Outer membrane lipooligosaccharide- endotoxin- high levels assc. w/ septic shock and death