Drugs 2 Flashcards
name an example of an anti - resorptive drug
(carries MRONJ risk)
denosumab
what is denosumab used to treat and what is its mechanism of action
oseteoporosis (MRONJ risk)
inhibits osteoclast formation
side effects of anti resorptive drugs e.g denosumab
increased infection risk
osteonecrosis
alopecia
sciatica
abdominal discomfort
name 2 examples of anti angiogenic drugs (MRONJ risk)
bevacizumab
aflibercept
sunitinib
what are anti angiogenic drugs used to treat and what is there mechanism of action
used for treating cancer
aim to restrict tumour revascularisation by inhibiting formation of new blood vessels
side effects of anti angiogenic drugs
osteonecrosis (MRONJ risk)
dry mouth
abscess
alopecia
anaemia
sepsis
name 2 examples of bisphosphonates
alendronic acid
ibandronic acid
zolendronic acid
what are bisphosphonates used to treat and what is there mechanism of action
treat osteoporosis
inhibit bone formation by inhibiting enzymes responsible for formation , recruitment and function of osteoclasts
side effects of bisphosphonates
alopecia
anaemia
osteonecrosis
altered taste
chills
fever
dysphagia
name 2 examples of proton pump inhibitors
omeprazole
lansoprazole
what are protein pump inhibitors used to treat and what is their mechanism of action
GIT ulceration, helicobacter pylori, GORD
inhibit gastric acid secretion
side effects of proton pump inhibitors
abdominal pain
constipation
diarrhoea
dry mouth
dizzyness
name 2 examples of antihistamines
loratadine
fexofenadine
cetirizine
antihistamines
- indication
- moa
- side effects
- allergy relief
- block effects of histamine
- drowsiness
name 3 examples of opioid analgesics
tramadol
co codamol
codeine
fentanyl
morphine
how do opioid analgesics work
attatch to opioid receptors on nerve cells throughout body thereby blocking pain messages sent from body through spinal cord to brain
side effects of opioid analgesics
addiction
withdrawal syndrome
respiratory depression
hallucinations
arrythmias
confusion
dry mouth
what type of drug is warfarin
anticoagulant - vitamin K antagonist
warfarin
- indications
- moa
atrial fibrillation, prosthetic valves, TA, embolism
antagonistic action against vitamin K therefore inhibits formation of factors 2,7,9,10
side effects of warfarin
haemmhorage
nausea
vomiting
(many drug interactions)
