drug therapy for immune suppression Flashcards

1
Q

why would you want to suppress the immune system?

A

inapropriate immune responses like…
- allergies
- autoimmune disorders
- transplant rejection

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2
Q

give examples of cytotoxic immunosuppressive agents

A
  • mycophenolate
  • methotrexate
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3
Q

describe the action of cytotoxic immunosuppressive agents

A

blocks cellular (B and T cells) reproductions, growth, and development

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4
Q

what are cytotoxic immunosuppressive agents used for

A
  • prevent organ rejection
  • treat autoimmune disorders
  • high dose for cancer tx
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5
Q

what are some adverse effects of cytotoxic immunosuppressive agents

A
  • GI effects
  • infection
  • malignancy
  • liver toxicity
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6
Q

whats a contraindication of cytotoxic immunosuppressive agents

A

pregnancy

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7
Q

name a conventional antirejection agent

A

cyclosporine

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8
Q

describe the action of conventional antirejection agents

A

reduce activity of immune (B and T) cells

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9
Q

what are conventional antirejection agents used for

A

transplant rejection

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10
Q

what are some adverse effects of conventional antirejection agents

A

black box warning for hypertension and nephrotoxicity

  • infections
  • cancers
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11
Q

whats a contraindication for conventional antirejection agents

A

pregnancy

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12
Q

describe monoclonal antibodies

A

created in a lab to suppress a specific component of the immune system that causes tissue damage in a specific disorder
- block cellular growth
- block cytokine release
- make cell more visible to immune system
- block growth signals

these end in -mab

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13
Q

give an example of a monoclonal antibody

A

adalimumab

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14
Q

describe the action of monoclonal antibodies

A

suppress immune system and decrease tissue inflammation

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15
Q

what are monoclonal antibodies used for

A

treat a variety of autoimmune diseases (RA, crohns)

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16
Q

what are some adverse effects of monoclonal antibodies

A
  • acute pulmonary edema
  • fluid retention
17
Q

what are some contraindications of monoclonal antibodies

A
  • active infection
  • fever
  • pregnancy
18
Q

give an example of cytokine inhibitor

A

abatacept

19
Q

describe the action of cytokine inhibitors

A
  • prevents the activation and production of cytokines
  • decreases inflammation and limits joint destruction
20
Q

what are cytokine inhibitors used for

A

rheumatoid arthritis

21
Q

what are some adverse effects of cytokine inhibitors

A
  • dizziness, HA
  • infection
22
Q

whats a contraindication of cytokine inhibitors

A

pregnancy

23
Q

what are some nursing considerations for immune suppressants

A
  • HAND HYGIENE
  • monitor temp
  • lifelong tx for organ transplant
24
Q

whats some patient teaching to include for cytokine inhibitors

A
  • HAND HYGIENE
  • clean environment
  • avoid fresh flowers
  • avoid fresh fruits and veggies
  • barrier contraception
  • routine cancer screenings
25
Q

monoclonal antibodies are made to target specific antigens. which of the following actions by monoclonal antibodies can be used on a target cell? (select all that apply)

1) make cell more visible to immune system
2) block growth signlas
3) block cytokine release
4) increse WBC count

A

1) make cell more visible to immune system
2) block growth signlas
3) block cytokine release

MABs are made to suppress a specific part of immune response or make cells more visible to immune system to stop tissue or cell damage