drug therapy for immune suppression Flashcards
why would you want to suppress the immune system?
inapropriate immune responses like…
- allergies
- autoimmune disorders
- transplant rejection
give examples of cytotoxic immunosuppressive agents
- mycophenolate
- methotrexate
describe the action of cytotoxic immunosuppressive agents
blocks cellular (B and T cells) reproductions, growth, and development
what are cytotoxic immunosuppressive agents used for
- prevent organ rejection
- treat autoimmune disorders
- high dose for cancer tx
what are some adverse effects of cytotoxic immunosuppressive agents
- GI effects
- infection
- malignancy
- liver toxicity
whats a contraindication of cytotoxic immunosuppressive agents
pregnancy
name a conventional antirejection agent
cyclosporine
describe the action of conventional antirejection agents
reduce activity of immune (B and T) cells
what are conventional antirejection agents used for
transplant rejection
what are some adverse effects of conventional antirejection agents
black box warning for hypertension and nephrotoxicity
- infections
- cancers
whats a contraindication for conventional antirejection agents
pregnancy
describe monoclonal antibodies
created in a lab to suppress a specific component of the immune system that causes tissue damage in a specific disorder
- block cellular growth
- block cytokine release
- make cell more visible to immune system
- block growth signals
these end in -mab
give an example of a monoclonal antibody
adalimumab
describe the action of monoclonal antibodies
suppress immune system and decrease tissue inflammation
what are monoclonal antibodies used for
treat a variety of autoimmune diseases (RA, crohns)
what are some adverse effects of monoclonal antibodies
- acute pulmonary edema
- fluid retention
what are some contraindications of monoclonal antibodies
- active infection
- fever
- pregnancy
give an example of cytokine inhibitor
abatacept
describe the action of cytokine inhibitors
- prevents the activation and production of cytokines
- decreases inflammation and limits joint destruction
what are cytokine inhibitors used for
rheumatoid arthritis
what are some adverse effects of cytokine inhibitors
- dizziness, HA
- infection
whats a contraindication of cytokine inhibitors
pregnancy
what are some nursing considerations for immune suppressants
- HAND HYGIENE
- monitor temp
- lifelong tx for organ transplant
whats some patient teaching to include for cytokine inhibitors
- HAND HYGIENE
- clean environment
- avoid fresh flowers
- avoid fresh fruits and veggies
- barrier contraception
- routine cancer screenings
monoclonal antibodies are made to target specific antigens. which of the following actions by monoclonal antibodies can be used on a target cell? (select all that apply)
1) make cell more visible to immune system
2) block growth signlas
3) block cytokine release
4) increse WBC count
1) make cell more visible to immune system
2) block growth signlas
3) block cytokine release
MABs are made to suppress a specific part of immune response or make cells more visible to immune system to stop tissue or cell damage
