drug therapy for immune and hematopoietic stimulation Flashcards
name an erythropoiesis-stimulating agent
epoetin alpha
describe the action of erythropoiesis-stimulating agents
synthetic erythopoitein, stimulates RBC production
what are some uses of erythropoiesis-stimulating agents
anemia
chemo induced or kidney failure
describe the pharmacokinetics of erythropoiesis-stimulating agents
- IM, IV
- 11-14 days onset
what are some adverse effects of erythropoiesis-stimulating agents
- hypertension (increase preload, increased work of heart, increased BP)
- black box warning: risk for MI
name a contraindication of erythropoiesis-stimulating agents
severe hypertension
what are some nursing considerations for erythropoiesis-stimulating agents
- monitor RBCs, Hgb, Hct
- goal Hgb no more than 12
- monitor BP
- need iron for drug to work
describe patient teaching for erythropoiesis-stimulating agents
- patient may be on an iron supplement
- vitamin C helps with iron absorbtion (fruit, juice, strawberries)
name come colony stimulating factors
- filgrastim
- pegfilgrastim
describe the action of colony stimulating factors
stimulates neutrophil production in bone marrow (increases WBCs)
what are colony stimulating factors used for
- prevent infection
- neutropenia from bone marrow transplant or chemo
what are some adverse effects of colony stimulating factors
- fatigue
- flu like symptoms
- bone pain
describe administration of colony stimulating factors
do not give 24hrs befoe or after chemo
wont get a good response
name an interferon
interferon alfa 2b
describe the action of interferons
increase overall response of immune system to viral infection or cancer