drug therapy for hematopoietic disorders Flashcards
what do hematopoietic growth factors do?
-regulate the differentiation and proliferation of particular progenitor cells
-growth factors control survival and proliferaion of hematopoietic lineages and also tranduce genuine lineage determining signal inhematopoiesis and initiate cell maturation process
what types of physiologic responses are hematopoietic growth facotrs involved in?
-hematopoiesis, inflammation
-cellular proliferation and differentiation
-wound healing; cellular and humoral immunity
what are hematopoietic cytokines
extrecellular ligands that stimulate hematopoietic cells to differentiate into eight principle types of blood cells
what do hematopoietic cytokines do?
regulate many cellular activities
-act as chemical messengers among cells
-act as growth factors for blood cells
perform binding to receptors on target cells
-trigger alteration of gene expression in target cells
what do colony stimulation factors (CSFs) do?
stimulate production of a ton of blood cell shit
-RBCs, platlets
-granulocytes
-neutrophils, basophils, eosinophils
-granulocyte-macrophages
-monocyte-macrophages
-other blood cell types
describe interferons
-inhibit replication of viral and other cells
-activate natural killer cells
describe interleukins
affect immunologic cell response
-stimulatory
-suppresive
where is erthyropoietin secreted from
erythropoietin is a hormone secreted by the kidneys
what does erythropoietin do?
-stimulates red blood cell differentiation, maturation, and proliferation
-increases the amount of RBCs which increases the oxygen carrying capacity of the blood
what conditions may trigger erythropoietin production
-hemorrhage
-anemia
-COPD
-high altitude
what does the immune system do
-detects and eliminates foreign substances that may cause tissue injury or diease
-regulates tissue homeostasis and repair
-immune system cells (WBCs) identify and remove injured, damaged, dead, or malignant cells
describe WBCs
-circulate in blood and lymphatic vessels or reside in lymphoid tissues
-ability to circulate and migrate
-major componenet of host defenses
-especially important in phagocytic immune responses
name some WBCS
-neutrophils
-eosinophils
-basophils
-monocytes
-lymphocytes
whats included in a CBC
-WBCs
-Hgb/Hct
-RBC
-platelets
what does a CBC with differential measure
meausures everything else as well as the number of each type of WBC
immune function indicates…
host protection from a disease
look at this stem cell shit