Drug/Receptor Theory

Question 1

Irreversible antagonist

Answer 1

A pharmacologic antagonist that cannot be overcome by increasing agonist concentration

Question 2

Physiologic antagonist

Answer 2

A drug that counters the e!ects of another by binding to a di!erent receptor and causing opposing e!ects

Question 3

Allosteric (noncompetitive) agonist, antagonist

Answer 3

A drug that binds to a receptor molecule without interfering with normal agonist binding but alters the response to the normal agonist

Question 4

Partial agonist

Answer 4

A drug that binds to its receptor but produces a smaller e!ect (Emax) at full dosage than a full agonist

Question 5

Inverse agonist

Answer 5

A drug that binds to the non-active state of receptor molecules and decreases constitutive activity/inverts Emax

Question 6

Graded dose- response curve

Answer 6

A graph of the increasing response to increasing drug concentration or dose

Question 7

Agonist

Answer 7

anything that binds to an effector and causes an effect

Question 8

Quantal dose- response curve

Answer 8

A graph of the increasing fraction of a population that shows a specified response at progressively increasing doses

Question 9

Spare receptor

Answer 9

Receptor that does not bind drug when the drug concentration is su!icient to produce maximal e!ect; present when Kd > EC50

Question 10

Receptor site

Answer 10

Specific region of the receptor molecule to which the drug binds

Question 11

How do spare receptors increase potency?

Answer 11

need lower drug concentrations to reach max effect

Question 12

EC50

Answer 12

drug concentration at which you get 50% of the max response/potency

Question 13

What is the relationship between EC50 and potency?

Answer 13

smaller EC50=greater potency

Question 14

Antagonist

Answer 14

any drug/molecule that block the effect of an agonist