drug main uses (Alpha Blockers) Flashcards
Phenoxybenzamine (Dibenzyline)
a1 & a2
- Decrease BP by decrease in peripheral arterial resistance
- Irreversible Non-competitive inhibition
Prevent severe catecholamine-induced hypertensive episodes from PRE-OP pheochromocytoma pts
Phentolamine (OraVerse)
a1 & a2
- Decrease BP by decrease in peripheral arterial resistance
- Irreversible Non-competitive inhibition
Short-acting drug used DURING Pheo surgery and in Dx of Pheo; reverse acute systemic vasoconstriction; prevent local dermal tissue necrosis from a-agonist injection; dental anesthetic reversal
Prazosin (Minipress)
Terazosin (Hytrin)
Doxazosin (Cardura)
a1
- Decreased peripheral arterial resistance
- Reversible Competitive inhibition
Decrease mild to moderate HTN when given with diuretic; relax smooth muscle of bladder neck and prostatic urethra in BPH; Tx of Reynaud’s; PTSD nightmares
Tamsulosin (Flomax)
Silodosin (Rapaflo)
a1
- Decreased peripheral arterial resistance
- Reversible Competitive inhibition
Block a1A receptor found in bladder neck and prostate to treat BPH with less systemic effect
Alfuzosin (Uroxatral)
a1
- Decreased peripheral arterial resistance
- Reversible Competitive inhibition
Treats BPH but not specific for a1A like above; still “uroselective” because of accumulation in prostatic tissue