drug main uses (Alpha Blockers) Flashcards

1
Q

Phenoxybenzamine (Dibenzyline)

A

a1 & a2

  • Decrease BP by decrease in peripheral arterial resistance
  • Irreversible Non-competitive inhibition

Prevent severe catecholamine-induced hypertensive episodes from PRE-OP pheochromocytoma pts

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2
Q

Phentolamine (OraVerse)

A

a1 & a2

  • Decrease BP by decrease in peripheral arterial resistance
  • Irreversible Non-competitive inhibition

Short-acting drug used DURING Pheo surgery and in Dx of Pheo; reverse acute systemic vasoconstriction; prevent local dermal tissue necrosis from a-agonist injection; dental anesthetic reversal

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3
Q

Prazosin (Minipress)
Terazosin (Hytrin)
Doxazosin (Cardura)

A

a1

  • Decreased peripheral arterial resistance
  • Reversible Competitive inhibition

Decrease mild to moderate HTN when given with diuretic; relax smooth muscle of bladder neck and prostatic urethra in BPH; Tx of Reynaud’s; PTSD nightmares

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4
Q

Tamsulosin (Flomax)

Silodosin (Rapaflo)

A

a1

  • Decreased peripheral arterial resistance
  • Reversible Competitive inhibition

Block a1A receptor found in bladder neck and prostate to treat BPH with less systemic effect

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5
Q

Alfuzosin (Uroxatral)

A

a1

  • Decreased peripheral arterial resistance
  • Reversible Competitive inhibition

Treats BPH but not specific for a1A like above; still “uroselective” because of accumulation in prostatic tissue

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