Direct Acting Muscarinic Agonists

Question 1

Acetylcholine

Answer 1

• glaucoma

- rapidly hydrolyzed by pseudocholinesterase

Question 2

Carbachol (Isopto Carbachol)

Answer 2

• acetylcholine analog
• cholinesterase resistant

main use: topical glaucoma

Question 3

Methacholine

Answer 3

• acetylcholine analog
• stims muscarinic only

main use: asthma testing

Question 4

Bethanechol (Urecholine)

Answer 4

• acetylcholine analog
• cholinesterase resistant
• stims muscarinic only

main use: stim GI motility, treat urinary retention

Question 5

Pilocarpine (Salagen, Ocusert Pilo)

Answer 5

main use: glaucoma, xerostomia d/t poor salivary secretion

Question 6

Cevimeline (Evoxac)

Answer 6

main use: salivary gland dysfunction