drug interactions

Question 1

Reyes syndrome

Answer 1

Mixed respiratory alkalosis with metabolic acidosis due to Aspirin toxicity

signs: Severe vomiting progresses to irrational behavior followed by stupor and coma, then to apnea, fixed pupils, and decorticate posturing with increasing brain edema, then eventually to death.

Question 2

Hydroxyurea

Answer 2

used in severe SCA to reduce the number of painful crises and incidences of acute chest syndrome (a leading cause of death in adolescents with SCA).