Drug Indications and Mechanisms Flashcards by Ryan Hutten

Indication for Metyrosine

Hypertension

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Indication for Reserpine

Hypertension

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Indication for Bretylium

Ventricular Arrhythmia

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Indication for Cocaine

Analgesia in surgery

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Indication for Amphetamine or Ephedrine

Narcolepsy, ADHD

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Indication for Naloxone, Naltrexone

Opioid overdose or dependence

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Indication for SSRIs

Depression/anxiety

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Indication for ACE inhibitors e.g., lisinopril

Hypertension

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Indication for Phenylephrine

Hypotension during surgery

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Indication for MAO inhibitors

Depression

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Indication for L-DOPA

Parkinson’s Disease

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Indication for Carbidopa

Parkinson’s Disease

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Indication for Tyramine

Ingested in diet, not therapeutic

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Mechanism of action of Metyrosine

Competitive inhibition of tyrosine hydroxylase

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Mechanism of action of Reserpine

Inhibits VMAT uptake of monoamines

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Mechanism of action of Bretylium

Inhibit action potential generation and calcium dependent synaptic vesicle fusion

Mechanism of action of Cocaine

Blocks monoamine reuptake,

Mechanism of action of Amphetamine or Ephedrine

Reverse monoamine reuptake transporters

Mechanism of action of Naloxone, Naltrexone

Non-peptide blockers of opioid receptors in CNS

Mechanism of action of SSRIs

Selective inhibition of serotonin reuptake transporter

Mechanism of action of ACE inhibitors e.g., lisinopril

Inhibits peptide cleavage of Angiotensin I to Angiotensin II

Mechanism of action of Phenylephrine

Direct agonist of adrenergic receptor

Mechanism of action of MAO inhibitors

Blockade of cytoplasmic metabolism of monoamines

Mechanism of action of L-DOPA

Precursor of dopamine, stimulates dopamine production

Mechanism of action of Carbidopa

Blocks L-DOPA conversion to dopamine, does not cross BBB, so protects peripheral adrenergic neurons from producing too much dopamine and norepinephrine

Mechanism of action of Tyramine

Competes with NE for transport into synaptic vesicle