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Pharmacology > Drug Indications and Mechanisms > Flashcards

Drug Indications and Mechanisms Flashcards

1
Q

Indication for Metyrosine

A

Hypertension

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2
Q

Indication for Reserpine

A

Hypertension

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3
Q

Indication for Bretylium

A

Ventricular Arrhythmia

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4
Q

Indication for Cocaine

A

Analgesia in surgery

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5
Q

Indication for Amphetamine or Ephedrine

A

Narcolepsy, ADHD

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6
Q

Indication for Naloxone, Naltrexone

A

Opioid overdose or dependence

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7
Q

Indication for SSRIs

A

Depression/anxiety

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8
Q

Indication for ACE inhibitors e.g., lisinopril

A

Hypertension

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9
Q

Indication for Phenylephrine

A

Hypotension during surgery

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10
Q

Indication for MAO inhibitors

A

Depression

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11
Q

Indication for L-DOPA

A

Parkinson’s Disease

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12
Q

Indication for Carbidopa

A

Parkinson’s Disease

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13
Q

Indication for Tyramine

A

Ingested in diet, not therapeutic

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14
Q

Mechanism of action of Metyrosine

A

Competitive inhibition of tyrosine hydroxylase

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15
Q

Mechanism of action of Reserpine

A

Inhibits VMAT uptake of monoamines

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16
Q

Mechanism of action of Bretylium

A

Inhibit action potential generation and calcium dependent synaptic vesicle fusion

17
Q

Mechanism of action of Cocaine

A

Blocks monoamine reuptake,

18
Q

Mechanism of action of Amphetamine or Ephedrine

A

Reverse monoamine reuptake transporters

19
Q

Mechanism of action of Naloxone, Naltrexone

A

Non-peptide blockers of opioid receptors in CNS

20
Q

Mechanism of action of SSRIs

A

Selective inhibition of serotonin reuptake transporter

21
Q

Mechanism of action of ACE inhibitors e.g., lisinopril

A

Inhibits peptide cleavage of Angiotensin I to Angiotensin II

22
Q

Mechanism of action of Phenylephrine

A

Direct agonist of adrenergic receptor

23
Q

Mechanism of action of MAO inhibitors

A

Blockade of cytoplasmic metabolism of monoamines

24
Q

Mechanism of action of L-DOPA

A

Precursor of dopamine, stimulates dopamine production

25
Q

Mechanism of action of Carbidopa

A

Blocks L-DOPA conversion to dopamine, does not cross BBB, so protects peripheral adrenergic neurons from producing too much dopamine and norepinephrine

26
Q

Mechanism of action of Tyramine

A

Competes with NE for transport into synaptic vesicle

Pharmacology (8 decks)

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