Drug Administration by Inhalation

Question 1

Advantages and disadvantages of drug administration by inhalation

Answer 1

Question 2

gas used in dpi

Answer 2

hydrofluoroalkane

Question 3

2 key determinants affect therapeutic efficacy

Answer 3

particle size of aerosol
velocity

Question 4

Determinants of aerosol deposition

Answer 4

Question 5

Particle size likely to be removed in the upper airways

Answer 5

> 5 to 10 um

*inhalation better in mouth

Question 6

Respirable range

Answer 6

1-7 um

Question 7

size of particle likely exhaled

Answer 7

less than 1 um
Brownian motion

Question 8

pattern of deposition

Answer 8

size - affects impaction and sedimentation
breath holding - sedimentation distally
inspiratory flow - impaction in upper and central airways

airway geometry

Question 9

what size deposits in lower and smaller airways

Answer 9

<3 um

Question 10

deposits in oropharynx and upper airways

Answer 10

> 5 um

Question 11

droplets of varying size

Answer 11

polydisperse aerosol droplets

Question 12

size unlikely to enter trachea

Answer 12

15 um

Question 13

in larger particles, as the velocity decreases, impaction occur in

Answer 13

oropharynx

Question 14

most important mechanistm for depostion

Answer 14

sedimentation due to gravity

Question 15

breatholding _____ seconds helps deposition in the airways due to sedimentation

Answer 15

10

Question 16

deposition if 0.1 to 1 um is by

Answer 16

aVERY slow
sedimentation and diffusion

Question 17

below 0.1 to 1 um, efficiency of deposition through the effects of _________ increases significantly

Answer 17

Brownian motion