diffuse alveolar hemorrhage Flashcards
cardinal feature of DAH
presence of hemosiderin-laden macrophage in the acinar units
when does Hemosiderin laden macrophage first appear? peaks at?
3 days after hemorrhage
peaks 7-10 days
continue until 2 months
most common cause of immune mediated DAH
ANCA-associated vasculitides
idiopathic pulmonary capillaritis
Caused of pulmo hge
bronchial circulation is ________ pressure,
_______ volume circuit that can cause massive hemoptysis and death.
HIGH pressure
low volume
caused if DAH
Patient has IDA, diffuse alveolar infiltrates, hemosiderin laden macrophages
but no systemic disease
negative autoimmune serology
Idiopathic Pulmonary Hemosiderosis
Tx for Idiopathic Pulmonary hemosiderois
steroids + or -
azathioprine/hydroxychloroquine
It is immune mediated, +anti pr3 antibodies(c anca pattern), affecting small to medium size blood vessels asssociated with necrotizing granulomatous inflammation
GranulomatoSIs with polyangitis
“Wegeners”
saddle nose deformity
sinusitis
otitis media
nodular or masses cavitation
pituitary gland
hematuria
cough, hemoptysis
Granulomatosis with polyangitis
or Wegeners
histopath fx of GP or wegeners
vasculitis
capillaritis
necrotizing granulomata
more common in children
pulmo renal sx
+ anti mpo antibodies (p anca pattern)
Microscopic polyangitis
limited to kung and kidneys
+ anti GBM antibodies
Anti GBM dx
Goodpasteur syndrome
elevated inflammatory markers without systemic manifestation
Isolated Pulmonary capillaritis
autosomal dominant
young age
ct scan: cystic disease
COPA syndrome
Table on clinical manifestation
