Drug Absorption Flashcards
What is meant by a pharmaceutical process?
The way in which a drug gets into the patients
What is the pharmacokinetic process?
How the drug moves through the body to the site of action
What is the pharmacodynamic process?
The pharmacological effect of the drug
Define the therapeutic process
Producing the desired therapeutic effect
What is ADME?
A - absorption
D - distribution
M - metabolism
E - elimination
List the different types of administration
Oral inhalation Intravenous intramuscular transdermal subcutaneous sublingual rectal nasal
Why is drug absorption important in drug administration
Drugs must be absorbed into the blood stream to allow for the drugs to get to the site of action
What is Tmax?
The time taken for a drug to peak in concentration
Define Cmax
The maximum concentration of the drug in the bloodstream
Define the therapeutic range
The range of concentrations at which the drug is active
Define the therapeutic index
The range of concentration that the drug is active but not toxic
Define drug bioavalability
The concentration of drug that reaches the site of action
What is the most effective drug administrative technique in terms of bioavalavility?
Intravenous
List factors that affect bioavalability
Formulation
Membrane permeability
GI effects
First pass metabolism
Define first pass metabolism
Metabolisim of a drug before it reaches its site of action
