Dougherty Part 11 Flashcards
what inflammatory myopathies respond to immunesuppression
Dermatomyositis
Polymyositis
where is the site of injury in dermatomyositis
capillary
what inflammatory myopathies have the endomysium myocyte as the injury site
polymyositis
inclusion body myositis
what cells mediate inclusion body myositis
CD8 T cells
what cells mediate polymyositis
CD8T cells
what cells mediate dermatomyositis
CD4 T cells and B cells
what inflammatory myopathies begin proximally
dermatomyositis
polymyositis
what is seen in thyrotoxic myopathy
exophthalmic ophthalmoplegia- profusion of eyeballs and diplopia due to orbital edema and contracture of the ocular muscles
acute or chronic proximal muscle weakness
what is seen in hypothyroidism myopathy
proximal weakness (posterior neck, CANT HOLD NECK UP) slow reflexes cramping/aching elevated CK fiber atrophy
Ethanol Myopathy is due to what
acute rhabdomyolysis after a drinking binge
ethanol myopathy can lead to what and why
myoglobinuria can lead to renal failure
drug-induced myopathies are normally due to what
steroids
chloroquine
statins
what is seen in drug-induced myopathies
proximal weakness
ICU myopathy aka myosin deficient myopathy presents who and is associated with what
profound weakness
associated with corticosteroids
myasthenia gravis is associated with what
thymoma-an epithelial neoplasm (10%) thymic hyperplasia (30%)
myasthenia gravis is due to what
neuromuscular junction disease immune mediated loss of acetylcholine receptors
circulating Anti AChR
Decreased AChRs
how does myasthenia gravis present
drooping eyelids
diplopia
generalized weakness (variable form minute-minute)
how is myasthenia gravis treated
thymectomy, anticholinesterase, prednisone, plasmapheresis
what occurs in myasthenia gravis to the response to repetitive nerve stimulation
the response diminishes
the tenselon test is used for what
myasthenia gravis
lambert-eaton myasthenic syndrome is almost always found in what type of patients
smokers
what cancer is lambert eaton myasthenia syndrome associated with
small cell carcinoma of the lung
what is the issue in lambert eaton myasthenia syndrome
neuromuscular junction disorder
antibodies inhibit presynaptic calcium channel and block acetylcholine release
what happen with repetitive stimulation in lambert eaton myasthenia syndrome
enhanced neurotransmission
lambert-eaton presents how
proximal weakness and autonomic dysfunction
