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Bone > Dougherty Part 11 > Flashcards

Dougherty Part 11 Flashcards

1
Q

what inflammatory myopathies respond to immunesuppression

A

Dermatomyositis

Polymyositis

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2
Q

where is the site of injury in dermatomyositis

A

capillary

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3
Q

what inflammatory myopathies have the endomysium myocyte as the injury site

A

polymyositis

inclusion body myositis

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4
Q

what cells mediate inclusion body myositis

A

CD8 T cells

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5
Q

what cells mediate polymyositis

A

CD8T cells

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6
Q

what cells mediate dermatomyositis

A

CD4 T cells and B cells

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7
Q

what inflammatory myopathies begin proximally

A

dermatomyositis

polymyositis

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8
Q

what is seen in thyrotoxic myopathy

A

exophthalmic ophthalmoplegia- profusion of eyeballs and diplopia due to orbital edema and contracture of the ocular muscles
acute or chronic proximal muscle weakness

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9
Q

what is seen in hypothyroidism myopathy

A 
proximal weakness (posterior neck, CANT HOLD NECK UP)
slow reflexes
cramping/aching
elevated CK
fiber atrophy
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10
Q

Ethanol Myopathy is due to what

A

acute rhabdomyolysis after a drinking binge

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11
Q

ethanol myopathy can lead to what and why

A

myoglobinuria can lead to renal failure

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12
Q

drug-induced myopathies are normally due to what

A

steroids
chloroquine
statins

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13
Q

what is seen in drug-induced myopathies

A

proximal weakness

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14
Q

ICU myopathy aka myosin deficient myopathy presents who and is associated with what

A

profound weakness

associated with corticosteroids

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15
Q

myasthenia gravis is associated with what

A 
thymoma-an epithelial neoplasm (10%)
thymic hyperplasia (30%)
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16
Q

myasthenia gravis is due to what

A

neuromuscular junction disease immune mediated loss of acetylcholine receptors
circulating Anti AChR
Decreased AChRs

17
Q

how does myasthenia gravis present

A

drooping eyelids
diplopia
generalized weakness (variable form minute-minute)

18
Q

how is myasthenia gravis treated

A

thymectomy, anticholinesterase, prednisone, plasmapheresis

19
Q

what occurs in myasthenia gravis to the response to repetitive nerve stimulation

A

the response diminishes

20
Q

the tenselon test is used for what

A

myasthenia gravis

21
Q

lambert-eaton myasthenic syndrome is almost always found in what type of patients

A

smokers

22
Q

what cancer is lambert eaton myasthenia syndrome associated with

A

small cell carcinoma of the lung

23
Q

what is the issue in lambert eaton myasthenia syndrome

A

neuromuscular junction disorder

antibodies inhibit presynaptic calcium channel and block acetylcholine release

24
Q

what happen with repetitive stimulation in lambert eaton myasthenia syndrome

A

enhanced neurotransmission

25
Q

lambert-eaton presents how

A

proximal weakness and autonomic dysfunction

Bone (19 decks)

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