DOHad

Question 1

Foetal development

Answer 1

Environment and nutrition during foetal development can cause permanent changed that could lead to disease later in life

Question 2

Barker Hypothesis

Answer 2

Barker and Osmond 1986

Alterations in foetal nutrition and endocrine status results in development adaptions that change child physiology and metabolism

Leading to predisposition of metabolic, cardiovascular or endocrine disease later

Question 3

Dutch Hunger Study

Answer 3

Dutch famine in 1944

First time famine hit in a country they had good health care

If famine hit in 1st trimester more likely to be obese

If famine hit in third then less likely

Question 4

DOHaD Overview

Answer 4

Development Origins of Health and Disease Hypothesis or Foetal origins hypothesis

States factors other than genetic makeup influence humans. This is as gene interacts with environment.

What mother eats leads to a phenotype being expressed in the wombs which persist during adulthood

Question 5

Factors effected by DOHaD

Answer 5

Casual early life exposure - transmitted by maternal traits
Maternal exposure around the time of pregnancy and early infancy
Paternal factors
Postnatal exposure

Question 6

Limiting factors in this area

Answer 6

Recruitments of fathers
Priority focus on mothers
Lack of information about postnatal