DLA5- Clinical Epidemiology, Summarizing Evidence, Meta-analysis

Question 1

list key differences between Systematic and Literature reviews

Answer 1

• Systematic answers a clinical question: more authors, mos-yrs
• Literature summarizes a topic: one or more authors, wks-mos to write

Question 2

literature review is also called….

Answer 2

narrative review

Question 3

what are the 4 parts needed to establish a research question

Answer 3

PICO:
Patient
Intervention
Comparison
Outcome

Question 4

what is a PRISMA flow chart used for and what are the 4 steps

Answer 4

• used in meta-analysis to screen what studies will be used in the study
  1) identification
  2) screening
  3) eligibility
  4) included

Question 5

what is the purpose of using multiple studies for a systematic review

Answer 5

able to obtain a more precise estimate of the effect size (estimates actual clinical effect of drug/therapy)

Question 6

compare fixed-effects and random-effects in terms of statistical analysis in a meta-analysis

Answer 6

Fixed: studies are more similar, no heterogeneity

Random: studies have different conclusions (heterogeneity)