Distribution and Excretion Flashcards by Eun Woo | Brainscape

Q

Mode of Administration: oral or rectal for GI imaging

A

Metallic salts

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Absorption: Not absorbed by the GI tract; remains within the lumen

A

Metallic salts

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Distribution: Localized in the GI tract for visualization of pathologies

A

Metallic salts

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Metabolism: Not metabolized by the body due to its insolubility

A

Metallic salts

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Exrection: Excreted unchanged via the GI tract; can cause constipation. Post-examination (after 24 hours) may be performed to ensure clearance

A

Metallic salts

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Contraindications: Contraindicated in patients with GI perforation, severe swallowing difficulties, severe constipation, or intestinal obstruction

A

Metallic salts

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Risks: Risk of impaction or peritonitis if leakage occurs into the abdominal cavity.

A

Metallic salts

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Mode of Administration: Direct injection into lymph nodes (e.g., for lymphography) or during bronchoscopy

A

Oily CM

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Absorption: Slowly absorbed by the lymphatic system

A

Oily CM

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Distribution: Phagocytized by polymorphnuclear cells; spreads through the lymphatic and circulatory systems

A

Oily CM

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

*Metabolism: Metabolized by esterase into sodium iodide in the panreas, liver, and salivary glands

A

Oily CM

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Excretion: Excreted via urine as inorganic iodine

A

Oily CM

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Contraindicated in patients with iodine allergies, advanced pulmonary disease, or renal dysfunction.

A

Oily CM

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Risks include adverse reactions to iodine and potential pulmonary embolism.

A

Oily CM

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Administered intravenously or intrathecally for certain neurological procedures

A

Water-Soluble CM (Ionic and Non-Ionic)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Absorption: Absorbed into the bloodstream through intravenous injection; intrathecal CM is absorbed into the bloodstream via the arachnoid villi

A

Water-Soluble CM (Ionic and Non-Ionic)

Q

Distribution: Distributed through the blood plasma; may diffuse into the extravascular space, causing potential extravasation.

A

Water-Soluble CM (Ionic and Non-Ionic)

Q

Metabolism: Minimal metabolism; remains largely unchanged in the bloodstream.

A

Water-Soluble CM (Ionic and Non-Ionic)

Q

Excretion: Primarily excreted via the kidneys through glomerular filtration

A

Water-Soluble CM (Ionic and Non-Ionic)

Q

Contraindicated in patients with iodine allergies or renal dysfunction.

A

Water-Soluble CM (Ionic and Non-Ionic)

Q

Risks include extravasation, nephrotoxicity, and allergic reactions.

A

Water-Soluble CM (Ionic and Non-Ionic)

Q

Mode of Administration: Administered intravenously, commonly used in MRI

A

Gadolinium-Based Contrast Media (GBCM)

Q

Absorption: Rapidly absorbed into the bloodstream following injection

A

Gadolinium-Based Contrast Media (GBCM)

Q

Distribution: Distributed through the vascular and extracellular, enhancing visualization of tissues with abnormal blood-brain barriers (e.g., tumors)

A

Gadolinium-Based Contrast Media (GBCM)

Q

Metabolism: Gadolinium is bound to a chelating agent to reduce toxicity and is not metabolized

A

Gadolinium-Based Contrast Media (GBCM)

Q

Excretion: Primarily excreted via the kidneys through glomerular filtration; excreted in the urine within 24 hours

A

Gadolinium-Based Contrast Media (GBCM)

Q

Contraindicated in patients with severe renal impairment due to the risk of nephrogenic systemic fibrosis (NSF).

A

Gadolinium-Based Contrast Media (GBCM)

Q

Risks include allergic reactions and nephrotoxicity

A

Gadolinium-Based Contrast Media (GBCM)

Q

Mode of Administration: Administered intravenously or inhalation, primarily used in ultrasound imaging

A

Microbubble Contrast Agent

Q

Absorption: Microbubbles remain within vascular space and are not absorbed by tissues

A

Microbubble Contrast Agent

Q

Distribution: Distributed within the bloodstream, enhancing the visualization of blood flow and improving the contrast in ultrasound imaging.

A

Microbubble Contrast Agent

Q

Metabolism: Microbubbles do not undergo traditional metabolism. The gas is expelled through normal respiratory processes

A

Microbubble Contrast Agent

Q

Excretion: The gas in the microbubbles is exhaled via the lungs, while the shell components (often lipid-based) are metabolized or excreted

A

Microbubble Contrast Agent

Q

Contraindicated in patients with severe pulmonary hypertension or right-to-left cardiac shunts

A

Microbubble Contrast Agent

Q

Risks include allergic reactions, but complications are rare.

A

Microbubble Contrast Agent