Distribution Flashcards
When a drug enters an area with a different pH and becomes ionized it undergoes a process called _____
- ion-trapping
- > gets trapped in the tissue
What plasma protein binder has a large capacity consisting of 50% of plasma proteins and has multiple binding sites
- Albumin
Lower free drug concentration has a high/low protein binding
- high protein binding
Effect of plasma protein binding on distribution?
- limits it
- protein bound drugs don’t pass membranes
- > wont leave circulation
Drug enriched in fat.
- lipophilic drugs
Low clearance has a higher/lower total drug concentration
- higher
Drug excluded by cell membranes. Gets out of circulation, but stays within extracellular fluid.
- very polar drug molecules
Concentrations in tissues are driven by the ________
- concentration in plasma (mostly)
Drug confined to circulation
- very large drug molecules
Organ perfusion rate
- % of the cardiac output
Who gets a higher dose of drugs neonates or adults?
- neonates because their body water concentration is higher
Neonates = 70-80%
Adults = 58%
What plasma protein binder has one specific binding site?
- Alpha-1 glycoprotein
If inflammation occurs will albumin or alpha-1 glycoprotein levels increase?
- alpha-1 glycoprotein
Distribution and depot storage depends on the ____
- volume of distribution
Where is albumin synthesized?
- the liver
