Adrenergic and Cholinergic Drugs

Question 1

Inhibits choline transport through inhibiting the high affinity transport system and uptake of Choline

Answer 1

• Hemicholinium

Question 2

Inhibits choline transport through inhibiting the vesicular transporter protein

Answer 2

• Vesamicol

Question 3

Blocks exocytosis of ACh

Answer 3

• Botulinum Toxin

Question 4

Binds to neurexins and releases neurotransmitters (ACh) followed by a permanent blockage of release

Answer 4

• Black Widow Spider Toxins

- > alpha-lactrotoxin

Question 5

Type of cholinesterase that is found in cholinergic neurons and is found in the blood and neuronal synapse. Performs hydrolysis of ACh to Acetate and Choline

Answer 5

• Acetylcholinesterase

- > choline is recycled for ACh synthesis

Question 6

Type of cholinesterase that is synthesized in the liver and released into the BLOOD. Found in the liver and plasma. Performs metabolism of certain drugs (succinyl choline) and esters.

Answer 6

• Butyrylcholinesterase (Pseudo chE)

Question 7

Causes an accumulation of ACh in the nerve terminal by further acting on muscarinic receptors and improving the cholinergic effect

Answer 7

• Acetylcholinesterase inhibitors

Question 8

Receptor that affects mainly skeletal muscle and is a ligand gated ion channel receptor

Answer 8

• nicotinic receptor

Question 9

Receptor that affects mainly visceral organs and smooth muscle. It is a G-protein coupled receptor with excitatory and inhibitory responses.

Answer 9

• muscarinic receptors

Question 10

Nicotinic Receptor found in the neuromuscular junction causes depolarization and skeletal muscle contractions

Answer 10

• Nm = Nicotinic muscular receptors

Question 11

Nicotinic Receptor found in the autonomic ganglion, adrenal medulla and CNS

Answer 11

• Nn = Nicotinic Neuronal receptor